Search results for " upstream" in Articles / App Notes
Article
Biopharma Says It Has an Evolution in New Technologies and Processes
Continuous processes currently are implemented in commercial manufacturing for upstream operations but not for downstream processes, the panelist noted. There is some potential for continuous manufact…
Article
Single-Use Chromatography: Adapting to Manufacturing Scale
While widely adopted in upstream production processes, what is required to move single-use technologies into downstream manufacturing scale?
This article discusses strategies for meeting the ever…
Article
Development and Future of Protein A Chromatography Technology: Q&A with Jonathan Royce, Business Leader Chromatography Resins, Cytiva
Increasing upstream titers can make the Protein A chromatography process step the rate-limiting step in downstream purification. Protein A chromatography columns are frequently too large, limiting the…
Article
Bioburden Control in the Biopharmaceutical Industry
…opriate selection of pre-filters rating and risk assessment studies that should be assessed for both upstream and downstream processes.
Good Practices in the Biopharmaceutical Industry
Becaus…
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Cost Considerations Drive Lean Technology in Biopharmaceutical Manufacturing
Alternatively, upstream process scale-up can make use of perfusion reactors, which use a constant supply of cell-culture media while removing unwanted byproducts throughout a prolonged production run …
Article
Automating Bioprocesses
By Jennifer Markarian
Both upstream and downstream biopharmaceutical processes have conventionally used stainless-steel equipment, but use of single-use systems (SUS) is becoming more established.…
Article
Improving Process-Scale Chromatography
Cytiva conducted several lifecycle assessments (LCAs) for complete mAb production processes, upstream to downstream, comparing single-use stainless-steel approaches.
LCAs provide a holistic perspe…
Article
Process Chromatography Selection for Downstream Processing Applications
It is important to also consider that changes in the upstream steps may impact the useful lifetime of the resin.
The process performance, for example aggregate removal on a cation exchanger, may b…
Article
Managing Biomanufacturing Capacity Expectations
It is more difficult to respond to shifting demands if process equipment and clean utility systems are hard piped into the infrastructure, says Parrish Galliher, CTO for upstream at Cytiva. Multiple c…
Article
Designing a Biomanufacturing Facility Incorporating Single-Use Technologies
Figure is courtesy of Cytiva
Starting with upstream, the status of the cell line and whether the process should be batch, fed-batch, or perfusion needs to be decided. Details about the nature of…