Search results for " upstream" in Articles / App Notes
Article
Successful Development of Scalable AAV Processes: Part 2 of 2
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In the second of a two-part series, Anki Magnusson, Staff Research Engineer, Protein and Viral Production, and Åsa Hagner-McWhirter, PhD, Senior Scientist, Bio…
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Strategies and Emerging Technologies for mAb Capture
Strategies will depend on the mode of upstream operations (fed batch or perfusion) and the desired process improvement of the capture step, (e.g., productivity, cost, or process time) as well as the t…
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Basics in Process Development for Biotherapeutics
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Definitions, activities, and things to consider when developing an upstream or downstream bioprocess.
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Reimagining Affordable Biosimilars
This is a multistep process involving upstream processes (e.g., bioreactor design), downstream processes (e.g., separation and purification technologies) for removal of impurities (e.g., extractables,…
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Strategizing for Rapid Changeovers in Biologics Manufacturing
Inclusion of multiple upstream suites can enable better utilization of downstream operations because upstream processing takes much more time, according to Stenklo.
For a multi-product downstream …
Article
Eliminating Residual Impurities Starts with a Strategic Plan
Numerous risk factors
Residual impurities in biopharmaceutical processes can be traced back to raw materials or can form during upstream or downstream processing steps and upon storage. They can b…
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New Therapies Present Scaling Challenges
Dependence on single-use formats limits the selection of upstream hardware that is currently available, however; downstream hardware are more limited because processing solutions that are currently av…
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Design Considerations for a Commercial Cell and Gene Therapy Facility
Both mAb bioprocessing and viral-vector manufacturing are usually divided into upstream and downstream processes. Upstream focuses on maximizing both the number of cells per bioreactor unit volume (e.…
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Addressing the Complex Nature of Downstream Processing with QbD
“From my understanding, the number of input parameters that can have a significant impact on product quality is higher in the large-molecule world due to the multiple biologically based upstream unit …
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The Challenge of Disruptive Technologies in Bioprocessing
“Higher productivity and higher throughput processes that integrate upstream and downstream unit operations are driving technology innovation downstream. Lastly, commercialization of gene and cell the…