Search results for " upstream" in Articles / App Notes
Article
Going Small to Achieve Success on the Commercial Scale
Scale-down models are used in the development of nearly every unit operation in the overall biopharmaceutical manufacturing process, including both upstream and downstream steps, and separation and fi…
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Selecting the Right Viral Clearance Technology
By Cynthia Challener, PhD
The introduction of adventitious viral agents is a recognized, inherent risk of biologic drug production that is well addressed by international regulatory requirements…
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Viral Clearance Challenges in Bioprocessing
Equipment and process failures, such as inadequate raw material screening or failure of an upstream inactivation method, particularly those that go undetected, are also a concern with respect to poten…
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Q&A with Industry Leaders: Rita Peters
Continuous processing is established in solid-dose manufacturing and is being used in upstream biopharmaceutical production. Strategies to connect upstream and downstream operations and extend continu…
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Unraveling the secrets of poloxamer 188 - A webinar mystery
When an inexplicable drop in cell culture performance is linked to a batch of media, researchers race to find the culprit.
In this on demand recording we will unravel the mystery as we …
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Digitalization: The Route to Biopharma 4.0
In upstream processing, researchers have demonstrated the value of automation in microscale bioprocesses (2). In microbial cell cultures, scale down models such as micro well plates (3) and deep well …
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How to develop a scalable rAAV process
Adeno-associated virus (AAV) is the most common vector for gene therapy, yet there’s much room to improve production, purification, and analytics. Here we present the latest updates to our wor…
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Accelerating CMC - The future of process development is in silico
Presented by Per Liden, General Manager, GoSilico at Cytiva.
Simulation for in silico process development is becoming a viable option to reduce the time needed for chemicals, manufacturin…
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Visualize the Xcellerex™ X-platform bioreactors in 3D
Bioreactors are integral to the manufacture of protein-based drugs, especially monoclonal antibodies. Xcellerex™ X-platform bioreactors from Cytiva are designed to meet process needs of today …
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Optimizing your Cell Culture Process to Improve Productivity
It allows us to make a better decision in the upstream process by understanding what is happening to the cells in culture. This may avoid bigger issues further down the process.
Jeanne Linke No…