Search results for " resin"
Article
Selecting the Right Viral Clearance Technology
“Column chromatography will frequently be effective for virus reduction, but the degree of reduction is dependent on the resin type (mode of action), the conditions used for the separation, and the ch…
Article
Securing the Single-Use Supply Chain
“Doing so is not as easy as it seems due to supply chain complexity down to the resin suppliers and the varying approaches that can be taken. It really starts with a close interaction with SUS integra…
Article
Challenges of Protein Aggregation During Purification
At the same time, strong hydrophobic interactions between the resin and the product may lead to aggregate formation, according to Vedantham, again due to surface-induced structural perturbation of the…
Article
Regulatory Challenges in the QbD Paradigm
The authors demonstrate how an integrated model is helping to achieve regulatory flexibility. This article is part of a special section on biopharmaceutical trends.
With the dawn of the 2…
Article
Optimizing KiH bispecific antibody chromatography steps
… capture step for two closely related knob-into-hole (KiH) bsAbs using MabSelect PrismA™ protein A resin which reached a purity of 94%. In addition, two flow-through polishing steps using orthogonal …
Article
In silico optimization of AAV full/empty particle separation with AIEX
We present a guiding workflow showcasing in silico process optimization of full and empty AAV5 particle separation on strong AEX resins, such as Capto™ Q ImpRes or Capto™ Q with GoSilico™ chromatograp…
Article
Video: The solution to smarter column packing
Packing modern chromatography resins at large scale requires a column capable of axial compression to ensure stable, reproducible packed beds. AxiChrom™ columns are low-pressure, axial compressi…
Webcast
Cytiva Protein Select Technology Live Webinar
On November 15 2023, Cytiva announced the upcoming launch of Cytiva™ Protein Select™ technology, an affinity chromatography resin for purifying recombinant proteins using the self-cleaving and tracele…
Article
Program finalized for the 6th HTPD and smart PD conference
Talks will cover everything from in silico PD and mechanistic modeling, HTPD approaches to chromatography resin screening and optimization, process characterization of gene therapy viral vectors to es…