Search results for " concentration" in Articles / App Notes
Article
New Therapies Present Scaling Challenges
New Therapies Present Scaling Challenges
Manufacturing differences between traditional mAb therapies and newer biotherapeutics dictate whether processes should be scaled up, scaled out, or use an al…
Article
Optimizing Drug Safety and Efficacy of Complex Next-Generation Biologics
In recent years, the global biopharma industry has seen a rapidly advancing trend toward biotherapeutics or ‘biologic’ drugs—drugs that are produced from living organisms or contain components of li…
Article
Best Practices for Selecting a Top-Quality Cell Line
By counting the number of fluorescent droplets versus the total number of droplets, the concentration of the target DNA strand can be determined.
Custom probes can be used to select for cells c…
Article
Emerging Therapies Test Existing Bioanalytical Methods
Sampling from biodistribution studies should be performed at multiple time points and should include time of expected peak concentrations along with multiple late time points to determine both distrib…
Article
Single-Use for Downstream Chromatography: Benefit or Hindrance?
Single-use technology is gaining ground in downstream bioprocessing, but challenges stall further adoption.
By Feliza Mirasol
ARTMOIS/STOCK.ADOBE.COM
Biopharmaceutical manufactu…
Article
The Outlook for CMO Outsourcing in 2019
By Eric Langer and Ronald A. Rader
Biopharmaceutical industry-related indicators and trends are supporting continued incremental increases in outsourcing of pre- and commercial AP…
Article
Achieving Process Balance with Perfusion Bioreactors
Advances in single-use technologies, sensors, and cell retention systems facilitate processes designed for the long run.
By Cynthia A. Challener
MG/Stock.Adobe.com
…
Article
Using Multiple Techniques in Biosimilar Analysis
Similarly, the formulation buffer may include excipients that cause some techniques to fail, or the formulation concentration of the API may be too low to detect using certain techniques. These occasi…
Article
Scaling Up Novel Therapies
“The key to exploiting this intensified upstream process is having downstream processing solutions that can handle the increase in mass and concentration of product and not become the process bottlene…
Article
The Challenge of Disruptive Technologies in Bioprocessing
“Achieving good capacity and separation under higher salt concentrations for added flexibility and process simplicity is important. A salt-tolerant resin can be beneficial to a purification process by…