Search results for " concentration" in Articles / App Notes
Article
Optimizing Late-Stage and Commercial Cell-Culture Processes
In Lonza’s experience, increases in viable cell concentration and maintaining high culture viability for longer duration have primarily contributed to productivity increases, rather than improvements …
Article
Biopharma Seeks Balance
Biopharma Seeks Balance
Biopharma companies can balance competing demands from patients, investors, and regulators by keeping a focus on science.
By Rita C. Peters
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Article
Fifteen Years of Progress: Biopharmaceutical Industry Survey Results
Fifteen Years of Progress: Biopharmaceutical Industry Survey Results
This article highlights 15 years of changes in biopharmaceutical manufacturing.
By Ronald A. Rader, Eric La…
Article
Putting Viral Clearance Capabilities to the Test
“Relevant viruses may be difficult or impossible to produce in high concentrations. Therefore, model viruses, preferably of the same genus or family, are used as substitutes,” says Gilljam.
“Even …
Article
Leveraging Data for Better Biopharmaceutical Process Control
However, the low concentrations and/or aqueous matrices involved created several challenges, particularly for NIR spectroscopy, due to a lack of sensitivity and specificity.
Monitoring calibrat…
Article
Making the Move to Continuous Chromatography
Some systems come with dynamic control functionality—process analytical technology (PAT)—that enables the continuous chromatography unit operation to better adapt to changes in feed concentration (whe…
Article
Impurity Testing of Biologic Drug Products
The commonly used analytical methods for characterizing these proteins include UV spectroscopy for concentration; SEC, analytical ultracentrifugation (AUC), and field flow fractionation (FFF) for aggr…
Article
Single-Use Workflow for Recovery of a Domain Antibody from E. coli Culture Feed in an Automated Manner
This application note demonstrates the performance of the automated ÄKTA™ readyflux single-use filtration system in microfiltration applications. Here, a domain antibody (dAb) expressed in E. col…
Article
Modeling and Miniaturization: Key Topics at Successful HTPD Conference
This year's clear winner was “Implementation of an Analytical Microfluidic Device for the Quantification of Protein Concentrations in a High-throughput Format” presented by Therese Schermeyer from Kar…
Article
Development and Future of Protein A Chromatography Technology: Q&A with Jonathan Royce, Business Leader Chromatography Resins, Cytiva
Although Protein A resins introduced to the market in the last 10 years withstand low to medium concentrations of sodium hydroxide for cleaning, like 0.1 M sodium hydroxide and in some cases 0.5 M, th…