Search results for " concentration" in Articles / App Notes

Article Using Digital Twins to Model Process Chromatography
[These conditions] may include a changing feedstream quality with respect to product or contaminant concentrations, variations in material quality, such as adsorber capacity and buffer composition, or…

Article Explore the Process Intensifier App
Explore alternatives to intensify your processes >> How do you know if an intensification approach will give you advantages over your current biomanufacturing process, and how do you choose the …

Article Cell-free Expression Systems Pose Cell Culture Alternative
New technologies for rapid, in-line assessments of product concentration, potency, and purity are also needed. Meanwhile, new analytical, quality assurance, and regulatory approaches are needed to imp…

Article Efficient Sodium Hydroxide Sanitization with a Novel Procedure of AxiChrom™ Columns Packed with Chromatography Resin
Here, we describe a microbial challenge test with a concentration of 1-M NaOH to mimic typical sanitization practices employed by the biopharma industry for a broad range of resins. The final version …

Article Sanitization Opportunities for Protein A Resins
Click here to read more >> Bacterial endospores present a challenge in bioproduction due to their resistance to common sanitization procedures using high concentrations of NaOH. Several protein-b…

Article Cytiva Advances Fiber Chromatography Technology with New Launch
The launch of HiScreen Fibro PrismA, the company’s newest product for early mAb purification process development strengthens Cytiva’s new fiber-based Protein A platform. On Jan. 27, 2021, Cyti…

Article Remote Monitoring and Big Data Advance Upstream Automation
…ty or direct integration with high-performance liquid chromatography instruments for at-line product concentration measurements, blurring the lines between historical upstream, downstream, and analyt…

Article Virus-like Particles as Therapeutic Moieties of the Future
NTA offers a non-invasive method to quickly analyze size distribution, identify aggregates, and calculate the concentration of particles (20). It is to be noted that enveloped, pleomorphic VLPs typica…

Article Reimagining Affordable Biosimilars
Advances in preclinical development play a crucial role in reducing cost for developing biosimilars.  By Anurag S. Rathore, Narendra Chirmule, and Himanshu Malani  Drug development is …

Article Mapping a Route for Cell and Gene Therapy Process Development
Precise in-process monitoring of complex parameters (metabolite concentrations, pH, oxygen and carbon dioxide, number and viability of the cells) within the bioreactor is necessary to gather the data …

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