Search results for " hybrid" in Articles / App Notes

Article Cell-Culture Advances Test Bioreactor Performance Models
More advanced use of hybrid models such as CFD combined with first principles kinetic models are also effective to assess the impact of bioreactor design on performance, according to Mistretta. “Use o…

Article Moving PAT from Concept to Reality
The learning curve for process analytical technology has slowed widespread adoption. By Cynthia A. Challener alexlmx a- Stock.Adobe.com Process analytical technology (P…

Article Supply Chain Challenges for Single-Use Systems
In a fully disposable or hybrid facility, however, because pieces of equipment (e.g., reactors, transfer tubing, holding vessels) are now consumables, the supply to the manufacturing facility is more …

Article Biopharmaceutical Process Development: 2018 Lessons and 2019 Predictions
   Of note, hybrid single-use systems still dominate biopharmaceutical production. Readers were particularly interested in the perspective of one writer who explained why he believes single-use te…

Article Scaling Up Novel Therapies
Scaling Up Novel Therapies Platform processes have improved monoclonal antibody scale-up. Can they do the same for personalized therapies? By Agnes S…

Article A Plastic Pipeline for Commercial Bioprocessing?
Whether companies choose a plastic, steel, or hybrid approach, the key factor in selecting a platform is determining what works best for the molecule, expert say. Jenifer Wheat, head of commerc…

Article Biopharma Says It Has an Evolution in New Technologies and Processes
There is some potential for continuous manufacturing to help in downstream operations, with hybrid configurations a potential solution. The panelists, however, expect the changes to be evolutionary, n…

Article Making the Move to Continuous Chromatography
Making the Move to Continuous Chromatography Early adopters are benefiting from lower costs and increased productivity. By Cynthia A. Challener Tashatuvango/Shu…

Article Impact of Media Components on CQAs of Monoclonal Antibodies
Major mammalian expression systems for the production of biotherapeutics include NS0 cells, baby hamster kidney (BHK) cells, hybridoma cells, PER.C6 cells, human embryonic kidney (HEK) cells, and Chin…

Article Mechanistic Modeling of Preparative Ion-Exchange Chromatography
While they are preferred over empirical models, the complexity of most chromatography operations does not lend itself to mechanistic modeling and hybridization of the mechanistic model. Traditional ap…

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