Search results for " hybrid" in Articles / App Notes
Article
Hybrid Bioprocessing: A Q&A with Andrew Sinclair
In reality, claimed SU manufacturing is hybrid bioprocessing. In the therapeutic protein space, there has not been a truly SU facility at commercial scale.
What could be the main reasons and/or th…
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Digitalization: The Route to Biopharma 4.0
This knowledge transfer can be channeled through process models that can be mechanistic, statistical, machine learning, or hybrid. Digital twins are becoming quite popular as a potential source of dat…
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Continuous Manufacturing: A Changing Processing Paradigm
GlaxoSmithKline’s new hybrid continuous-batch synthesis manufacturing plant in Jurong, Singapore—announced in October 2014 and predicted to open in 2016—cost 19 million euros (approximately $25 millio…
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Reducing Cross-Contamination Risks in Process Chromatography
Hybrid solutions
With single-use systems providing advantages for some, but not all, process chromatography applications, often biopharmaceutical manufacturers use hybrid solutions that incorp…
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Technologies and Practices Must Evolve to Meet Demand
Users of stainless steel, single-use, and hybrid systems identified time savings and reduced contamination as the greatest advantages to disposable equipment. Flexibility for multi-product manufacturi…
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Remote Monitoring and Big Data Advance Upstream Automation
“Software is now providing the ability to implement hybrid models that combine standard data with PAT data, including mechanistic relationships. This ability has enabled machine learning (ML) to be ap…
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Full Single-Use Downstream Process? Not Any Time Soon.
But where we see full single-use upstream processes, downstream is often a hybrid solution. Here’s why SUTs will not completely replace reuse systems in the near future.
Continue reading in this…
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What You Need to Know about Continuous Processing
Could a hybrid of batch and continuous unit operations be the best solution for your process train?
Read this blog post to get quick insight on some challenges and opportunities and the import…
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Managing Biomanufacturing Capacity Expectations
Companies such as Amgen, Bristol-Myers Squibb, and Roche use hybrid approaches for the production of their medications. Wyss estimates that almost all biotech companies that have several products on t…
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Tackling Analytical Method Development for ADCs
One approach is to use hybrid techniques such as affinity capture LC-MS/MS, but that adds complexity to the analysis. A combination of immunoassay and LC-MS/MS techniques can also be used in addition …