Search results for "filtration"

Article Improving Upstream Predictability
Univercells has leveraged process intensification in a new single-use bioreactor design that features a structured fixed-bed bioreactor connected to an automated tangential flow filtration concentrato…

Article Mapping a Route for Cell and Gene Therapy Process Development
In addition, the downstream processing steps can vary significantly depending on the product specifications and available downstream technologies, such as tangential flow filtration, counter-flow cent…

Article New Therapies Present Scaling Challenges
New Therapies Present Scaling Challenges Manufacturing differences between traditional mAb therapies and newer biotherapeutics dictate whether processes should be scaled up, scaled out, or use an al…

Article Addressing the Complex Nature of Downstream Processing with QbD
When platform data already exist, others may require less study, such as affinity chromatography steps, low-pH viral inactivation, and nanofiltration, says MacDonald. “There can always be a need to st…

Article Sephadex™ Size Exclusion Resin Turns 60
Do you know the story behind Sephadex, which enabled today's large-scale production of biopharmaceuticals? An inadvertent discovery in 1959 became the foundation for today's biopharma industry. This i…

Article Analytical SEC: How Does Back Pressure Relate to Resolution?
High resolution in HPLC is not achieved by applying back pressure to the column. Let’s straighten out what really helps you achieve high-resolution analytical SEC data. Read paper

Article Protein Analysis with Size Exclusion Chromatography
Size exclusion chromatography (SEC) is widely used in several different analytical applications from basic research to quality control of biotherapeutics. This white paper presents fundamentals abou…

Article Achieving Process Balance with Perfusion Bioreactors
Alternating tangential flow (ATF) filtration technology (developed by Refine Technology, now Repligen) is commonly used. For perfusion processes used to manufacture chimeric antigen receptor (CAR)…

Article Scalable Viral Vector Manufacturing
For example, single-use bioreactors, filtration, and chromatography techniques are suitable for virus production. Due to the diversity of viruses, platform solutions are challenging to implement e…

Article Scaling Up Novel Therapies
Scaling Up Novel Therapies Platform processes have improved monoclonal antibody scale-up. Can they do the same for personalized therapies? By Agnes S…

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