Search results for "filtration"
Article
State of the Biopharmaceutical Industry: Lessons from 2018 Survey Data
• The downstream areas seen as needing the most improvements are now single-use purification, continuous downstream purification, and virus filtration. Again, desires for single-use technology took th…
Article
Putting Viral Clearance Capabilities to the Test
“Virus retentive filtration is based on size exclusion, and a model of a specific size will represent all viruses of the same or greater size. But removal with chromatography steps is based on the vir…
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Optimization of Adenovirus Midstream Purification Steps
Based on the results, suggestions for the choice of consumables and conditions for virus release and filtration is described.
To read the application note, click here.
Article
Industry Adoption of Single-Use Systems Remains Low
Now we have a complete portfolio of single-use upstream and downstream systems for bioprocessing, including rocking and stirred tank bioreactors, sensors, smart mixers, filtration pump skids, virus in…
Article
Single-Use Workflow for Recovery of a Domain Antibody from E. coli Culture Feed in an Automated Manner
This application note demonstrates the performance of the automated ÄKTA™ readyflux single-use filtration system in microfiltration applications. Here, a domain antibody (dAb) expressed in E. col…
Article
Development of Purification for Challenging Fc-Fusion Proteins
Development of Purification for Challenging Fc-Fusion Proteins
This study outlines methods for an alternative protein-polishing process for challenging proteins.
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Article
Modeling and Miniaturization: Key Topics at Successful HTPD Conference
The second downstream session,“Case Studies Downstream Part II: Other Techniques,” chaired by Ashley Hesslein from Bayer HealthCare, not only covered additional techniques such as cross flow filtratio…
Article
Process Chromatography: Continuous Optimization
“Using tangential flow filtration (TFF) between steps reduces product yield and lengthens process times. A salt-tolerant resin can be very beneficial to a purification process by decreasing the need f…
Article
From Darwin to Recombinant Fc Multimers
One case study presented by Gert Verheyden at Shire showed that the orientation of depth filter membrane during assembly can have significant impact in achieving a robust filtration step. Joakim Lundk…
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Extractables Studies for Single Use Systems Used in ADC Manufacturing, Part 1
Single‑use (SU) systems have great potential in antibody‑drug conjugates (ADC) manufacturing. The use of organic solvents in the ADC process might , however, raise questions about potential leac…