Search results for "filtration"
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Connected Inline Conditioning for Better Process Efficiency
In this study, we integrated an inline conditioning (IC) system that served as a buffer preparation skid with chromatography and filtration systems. This automated the buffer preparation p…
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Enhancing Resins Addresses Purification Concerns
“There are several purification techniques that are in use, such as precipitation, tangential flow filtration, or chromatographic separations. However, precipitation or size-exclusion chromatography (…
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Implementing Inline Conditioning to Advance Process Intensification
With inline conditioning buffers can be prepared inline from buffer concentrates or stock solutions, and directly integrated with the chromatography or filtration step. This eliminates the need for in…
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Commercial Production of Gene Therapies Using Suspension or Adherent Cell Lines
Instead, either the cells are concentrated using filtration or the mix is added directly to the cell culture. Each suffers drawbacks: concentration is an extra step that takes time and needs to be dev…
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Setting Up Bioprocessing Systems for Digital Transformation
Meanwhile in downstream processing, chromatography and tangential flow filtration (TFF) systems also gather different, but significant amounts, of data, which can be used to monitor and control proces…
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Innovative Chromatography Resins Can Improve Purity and Quality
Recent advances in chromatography resins can effectively impact the purification unit operation with positive consequences that reverberate both upstream to the bioreactor and downstream to filtration…
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Testa Challenge 2020 Attracts Leading International Bioprocessing Innovators
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Six bioprocessing innovators have successfully completed the inaugural Testa Challenge 2020. Held over an intensive week in the Testa Center located at Cytiva´s Uppsala…
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Strategizing for Rapid Changeovers in Biologics Manufacturing
For instance, he notes that a tangential-flow filtration skid can be equipped with small and large pumps and the ability to take small and larger single-use tubing sizes to accommodate a wide range of…
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Good Manufacturing Practices: Challenges with Compliance
There is an underlying assumption in regulations that most biologics are destined for simple filtration and sterile fill, with little attention given to non-traditional, more complex dosage forms.
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Gene Therapies Push Viral Vector Production
Gene Therapies Push Viral Vector Production
Viral vectors show promise as a delivery mechanism for gene therapy, but which virus types are commercially viable?
By Feliza Miraso…