Search results for " upstream" in Articles / App Notes
Article
Current Trends in Host Cell Protein Detection for Biologics Manufacturing
Commonly accepted HCP analytical methods, the challenges of HCP assay, and recommendations on what can easily be accomplished in-house and when it may be better to outsource.
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Using Digital Twins to Model Process Chromatography
In a situation where thousands of experimental conditions can be evaluated in silico, including variation in upstream feed or material quality, one can mechanistically understand the dynamics and deve…
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Commercial Production of Gene Therapies Using Suspension or Adherent Cell Lines
This article will explore the traditional path from the laboratory to the clinic and how the fixed-bed technology provides an alternative solution to meet commercial demands.
By Alex Chatel and …
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Assessing Manufacturing Process Robustness
This will include, but will not be limited to, materials, upstream and downstream process parameters, equipment parameters, hold times, operational variables, operation/analytical personnel, instrumen…
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Innovative Chromatography Resins Can Improve Purity and Quality
Recent advances in chromatography resins can effectively impact the purification unit operation with positive consequences that reverberate both upstream to the bioreactor and downstream to filtration…
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Virtual Scientific Symposium: Process Development: Go Smarter, Go Faster!
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In this free virtual symposium, you'll hear from leaders at GlaxoSmithKline, Byondis, UCB, UCL, GoSilico, and Cytiva on how they balance innovati…
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Meeting the Process Development Challenges of a Diverse Biologic Pipeline
While these novel biologics are filling drug pipelines, they are also challenging existing manufacturing processes in upstream, downstream, and analytical development.
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Making Your Bioprocesses More Efficient
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Bioprocess intensification lets you maximize productivity while minimizing one or more key variables of your current biomanufacturing proces…
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Developing a Closed, Connected Single-Use mAb Purification Process
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Learn more on this case study to set up a closed and connected single-use monoclonal antibody (mAb) purification process that addresses a perfusion upstream process. In the Pr…
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Single-Use Technologies Are Here to Stay: How Can We Improve Their Supply?
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The use of single-use technologies has been growing steadily, but supply constraint is a key challenge for the biopharma industry. This article discusses the potenti…