Search results for " resin"
Article
Single-Use Technologies Prove Effective for Viral Vector Process Development
… the sudden increase in manufacturing capacity demand has put more pressure on the supply of polymer resins used for the manufacture of single-use components, resins that are also used to produce cli…
Article
Setting Up Bioprocessing Systems for Digital Transformation
Hahn points out that, for instance, pre-packed single-use chromatography columns of the same type may differ in terms of column packing and resin lot capacity. “In practical application, these differe…
Article
What If You Could Remove Your Antibody Aggregates Already in the Protein A Step?
…lution buffer type, (2) conductivity of the elution buffer, (3) pH gradient length and (4) Protein A resin type.
Article
Mechanistic Modeling: Current Advantages and Future Opportunities in Biopharmaceutical Process Development
The actual interactions of molecules with the ligands on the resin do not change.
In summary, I am convinced that soon, modeling will be an asset in de-risking drug manufacturing but also the pro…
Article
Next Generation Process Chromatography
…ve pressure while carrying out the same purification that are currently achieved with chromatography resins at slower rates. Other convective flow adsorbers have existed in bioprocessing for many yea…
Article
Introducing Process Characterization Kit: New Tools for Gaining Deeper Chromatography Process Understanding
The kits provide critical insights on resin variation within the ligand density specification interval. With these insights, you can develop a solid control strategy for a robust downstream process.
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Article
New Therapies Present Scaling Challenges
In the case of gene therapy, the resins would be specific to the capsid protein. The downstream purification aspect lends itself nicely to standard purification technology. Although there are many tec…
Poster
To Speed Up the Process Optimization of the Described Biosimilar Product
When establishing purification processes for a biosimilar molecule it is important to develop steps that are scalable, selective and cost effective.
This example describes a standardized workflo…
Article
Single-Step, Protein A Chromatography Process for Bispecific Antibodies in Early Screening
MabSelect™ PrismA protein A resin was selected for the capture step. Most fragments could be removed as early as the capture step using gradient elution from pH 5 to 3.5, without the need for addition…
Article
Preclinical Evaluation of Product Related Impurities and Variants
The selection of resin, as is known, is guided by the physicochemical properties of the mAb product under investigation. In this case study, the mAb product had the following characteristics: pI, 7.9-…