Search results for " resin"
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The Development and Application of a Monoclonal Antibody Purification Platform
After cation exchange, diafiltration was performed to prepare the product for anion exchange chromatography in flow through mode, in which impurities such as DNA and some HCPs were captured on the res…
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Alternative solutions to separate AAV full and empty capsids using anion exchange
Optimized protocols and conditions for both resin and membrane formats are described. Full and empty capsid peaks were identified using the UV260:280 ratio from chromatograms. And separation results w…
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Production of recombinant proteins using a novel affinity technology
This scientific paper from Journal of Chromatography A describes results of a study utilizing a Cytiva Protein Select™ affinity resin and tag platform to produce any recombinant proteins.
Re…
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Detailed agenda for Chromatography + filtration virtual summit
We will also discuss recent innovations, such as Cytiva™ Protein Select™ technology, MabSelect™ VH3 resin, and MabSelect VL resin.
Registration is free of charge - see you there!
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Get Started: Purification of mAb Variants - eLearning
- Understand which resins are suitable for the first capture step.
- Discover the different strategies for removal of product- and process-related impurities in the polishing steps.
ACCESS TRAIN…
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Chromatography processes for the diversified therapeutic antibody pipeline
The diversity of antibody variants in today’s pipeline presents unique challenges for purification and we see molecules such as bsAbs, Fabs, dAbs, and others. Conventional chromatography protocols, …
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Top Process Development Trends for 2022 and a Look into 2023
Updates on purification advances continued in, “Enhancing Resins Addresses Purification Concerns,” which addresses purification concerns through advanced resin use.
Nuts-and bolts-detailed article…
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Dynamic Binding Capacity in Fiber-Based Chromatography
Fiber chromatography matrices such as Fibro PrismA can bind a large amount of protein in a fraction of the purification time required for an affinity resin. Just like with resins, the dynamic binding …
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Approaches to scaling up Chromatography Processes
Scaling up chromatography resins requires a thorough understanding of their intended use.
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Inspect Your Chromatography Column to Ensure You Get It Right
Or even space between the resin bed and the adaptor?
This is a sign that something is wrong with your column, and it can’t be used with confidence for purifying your protein. But don’t let it get y…