Search results for " screening" in Articles / App Notes
Article
Fermentation for the Future
Given that there is a strong dependence between protein structure and performance of protein-based drugs, extensive refolding know-how and high-throughput screening capabilities are key to achieving t…
Article
DoE Provides Benefits, but Preparation Is Necessary
LaBrenz believes that the challenges of a limited design space and the management of large quantities of data can be ameliorated with the adoption of high-throughput screening (HTS) techniques that pr…
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Challenges of Protein Aggregation During Purification
Currently, high throughput screening techniques are used during the candidate selection phase to select a construct (protein) that is less prone to aggregation, as well as a cell line and cell culture…
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Predicting Progress in Protein Aggregation
The most important recent advances in this technology, however, have been in the development of informatics tools, such as Waters’ DynamX software, that enable much more rapid screening of the data pr…
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Regulatory Challenges in the QbD Paradigm
A QbD inspection would evaluate the overall control strategy, including elements of facility and equipment qualification and maintenance as well as raw material screening and supplier management. Spec…
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Quality by design for biotechnology products—part 1
Further selection and screening may involve recombinant cloning from hybridomas, humanization, and fusions (e.g., Fc or human serum albumin, PEGylation) and the use of stringent parameters like in vit…
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Program finalized for the 6th HTPD and smart PD conference
Talks will cover everything from in silico PD and mechanistic modeling, HTPD approaches to chromatography resin screening and optimization, process characterization of gene therapy viral vectors to es…
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Optimization of an antibody polishing step
Optimal operating conditions for single units are found by altering just a few process parameters with Design-of-Experiment (DoE) procedures or high-throughput screenings. But what if DoE fails to fin…
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Accelerating VLP purification process development
See how using mechanistic modeling can speed up the purification process development of virus-like particles (VLPs).
Indeed, a method for the large-scale production of VLPs is produ…
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Enhancing Resins Addresses Purification Concerns
Protein A affinity chromatography provided one simple capture step that made screening of clones faster and purification process development simpler,” he states.
Deorkar also explains that p…