Search results for " screening" in Articles / App Notes
Article
Advances in Engineering of Protein-Based APIs
Amgen has developed a next-generation antibody engineering strategy that enables reliable and efficient identification of pre-candidate leads from early screening lead molecules. “We translate patient…
Article
Optimization of Fed‑Batch Culture Conditions for a mAb‑Producing CHO Cell Line
This application note describes a broadly applicable and efficient workflow toward finding the optimal feed combination for the best-performing fed-batch processes.
An IgG1-producing CHO cell …
Article
N-Glycan Analysis of Biotherapeutic Proteins
Ease and speed of analyses make it more attractive to examine N-glycan composition in the earlier stages of biotherapeutic process development such as during clone selection and screening, where sampl…
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Downstream Processing for Cell-Based Therapies
The development of bench-scale technologies that better mimic the full scale will be paramount to the rapid development of robust DSP processes and allow cost-effective screening of the susceptibility…
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Improving Process-Scale Chromatography
For example, Cytiva is currently using high-throughput screening techniques to screen hundreds of ligand designs with the goal of further improving process economy and robustness in mAb manufacturing …
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High-Throughput Process Development Handbook
However, screening optimal process conditions can be time-consuming and tedious. In addition, steadily increasing demands from regulatory authorities for better understanding and control of manufactur…
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A Platform Approach for the Identity Testing of Multi-Component Cell-Culture Media
Therefore, this approach (NIR and Raman spectroscopy coupled with chemometrics analysis) is more useful for the identification of media components and screening consistency and characterization of med…
Article
Tools for Continuous Bioprocessing Development
The device can use up to 324 cultures simultaneously, allowing it to be used for process optimization, screening, and media optimization (14, 15).
• Most recently, Sartorius Stedim’s TAP ambr 15 an…
Article
Use of Multivariate Data Analysis in Bioprocessing
Figure 3 illustrates an example of use of near-infrared spectroscopy/multivariate data analysis (NIR-MVDA) for screening of lots of basal medium powders based on their impact on process performance an…
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Detecting Protein Aggregates and Evaluating their Immunogenicity
With MFI, researchers can now determine how particle groups vary in their samples, and with “new high-throughput screening software, users can instantly compare results across many samples,” notes Olc…