Search results for " screening"
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Tools for Continuous Bioprocessing Development
The device can use up to 324 cultures simultaneously, allowing it to be used for process optimization, screening, and media optimization (14, 15).
• Most recently, Sartorius Stedim’s TAP ambr 15 an…
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Use of Multivariate Data Analysis in Bioprocessing
Figure 3 illustrates an example of use of near-infrared spectroscopy/multivariate data analysis (NIR-MVDA) for screening of lots of basal medium powders based on their impact on process performance an…
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Detecting Protein Aggregates and Evaluating their Immunogenicity
With MFI, researchers can now determine how particle groups vary in their samples, and with “new high-throughput screening software, users can instantly compare results across many samples,” notes Olc…
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Fermentation for the Future
Given that there is a strong dependence between protein structure and performance of protein-based drugs, extensive refolding know-how and high-throughput screening capabilities are key to achieving t…
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DoE Provides Benefits, but Preparation Is Necessary
LaBrenz believes that the challenges of a limited design space and the management of large quantities of data can be ameliorated with the adoption of high-throughput screening (HTS) techniques that pr…
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Challenges of Protein Aggregation During Purification
Currently, high throughput screening techniques are used during the candidate selection phase to select a construct (protein) that is less prone to aggregation, as well as a cell line and cell culture…
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Predicting Progress in Protein Aggregation
The most important recent advances in this technology, however, have been in the development of informatics tools, such as Waters’ DynamX software, that enable much more rapid screening of the data pr…
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Regulatory Challenges in the QbD Paradigm
A QbD inspection would evaluate the overall control strategy, including elements of facility and equipment qualification and maintenance as well as raw material screening and supplier management. Spec…
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Quality by design for biotechnology products—part 1
Further selection and screening may involve recombinant cloning from hybridomas, humanization, and fusions (e.g., Fc or human serum albumin, PEGylation) and the use of stringent parameters like in vit…
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Program finalized for the 6th HTPD and smart PD conference
Talks will cover everything from in silico PD and mechanistic modeling, HTPD approaches to chromatography resin screening and optimization, process characterization of gene therapy viral vectors to es…