Search results for " screening"
Article
Increase Efficiency in Experimentation with Design of Experiments
Design of experiment will not only save you valuable time during screening and optimization, but it will also provide a more rigid and robust process with better end results.
Learn more about …
Article
Advances in Engineering of Protein-Based APIs
Amgen has developed a next-generation antibody engineering strategy that enables reliable and efficient identification of pre-candidate leads from early screening lead molecules. “We translate patient…
Poster
High-Throughput Downstream Processing Using Cellulose Fiber Chromatography and ÄKTA™ Chromatography Systems
Developing a process or looking for a clone of interest often requires screening large numbers of samples. Many analyses require purified proteins, and often substantial hands-on time is required for …
Article
Optimization of Fed‑Batch Culture Conditions for a mAb‑Producing CHO Cell Line
This application note describes a broadly applicable and efficient workflow toward finding the optimal feed combination for the best-performing fed-batch processes.
An IgG1-producing CHO cell …
Article
N-Glycan Analysis of Biotherapeutic Proteins
Ease and speed of analyses make it more attractive to examine N-glycan composition in the earlier stages of biotherapeutic process development such as during clone selection and screening, where sampl…
Poster
Strategies for optimized cell culture media: Effectively using design space to influence product quality
First, a screening model is used to identify the key components that influence critical culture attributes (e.g., titer, protein quality). Multivariate analysis can be used to identify factors correla…
Article
Downstream Processing for Cell-Based Therapies
The development of bench-scale technologies that better mimic the full scale will be paramount to the rapid development of robust DSP processes and allow cost-effective screening of the susceptibility…
Article
Improving Process-Scale Chromatography
For example, Cytiva is currently using high-throughput screening techniques to screen hundreds of ligand designs with the goal of further improving process economy and robustness in mAb manufacturing …
Article
High-Throughput Process Development Handbook
However, screening optimal process conditions can be time-consuming and tedious. In addition, steadily increasing demands from regulatory authorities for better understanding and control of manufactur…
Article
A Platform Approach for the Identity Testing of Multi-Component Cell-Culture Media
Therefore, this approach (NIR and Raman spectroscopy coupled with chemometrics analysis) is more useful for the identification of media components and screening consistency and characterization of med…