Search results for " screening"
Article
Using Quality by Design to Develop Robust Chromatographic Methods
If structures are known, then the experimental screening strategy may be supplemented by the information to be gleaned from a Log(P) vs. pH plot (P is the octanol water distribution coefficient of all…
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Design of Experiments for Analytical Method Development and Validation
Textbook approaches to DOE generally suggest a sequential approach to DOE: screening studies, characterization studies, and optimization of the method or process. This approach applied to analytical m…
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Digitalization: The Route to Biopharma 4.0
High-Throughput Screening Techniques for Rapid PEG-Based Precipitation of IgG4 mAb from Clarified Cell Culture Supernatant. Biotechnol. Prog. 2010, 26, 697–705.
3. Dörr, M; Fibinger M. P. C.; La…
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Technology Innovations Improve Process Chromatography Performance
Meanwhile, the amount of effort needed to perform screening experiments poses another major challenge. Customers can benefit from working with vendors that support them with high throughput screening …
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Scaling Up Novel Therapies
In addition, he says, it will speed up and allow for screening of a much larger number of variants for mAbs, bispecifics, trispecfics, fragments, and recombinant proteins. For some cell therapies, the…
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Tackling Analytical Method Development for ADCs
Feb 01, 2015
By Cynthia Challener, PhD
BioPharm International
Volume 28, Issue 2
The targeted therapy possible with antibody-drug conjugates (ADCs) makes them an attractive class of …
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Buffer optimization for separation of bsAb in a capture step using MabSelect™ VL resin
The video includes results of these experiments and a discussion of how buffer screening enables improvements in terms of increased elution pH and resolution.
Watch video
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Advances in Sterilization Technologies for Overcoming Viral-Vector Manufacturing Challenges
Indeed, conducting a screening study to identify filters that perform best at small-lab scale followed by their evolution at larger-lab scale is recommended before deciding on the best options for ups…
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Cell-free Expression Systems Pose Cell Culture Alternative
…en realized (2)
• Industrial applications are being advanced (3)
• Protein screening workflows have been accelerated (4)
• Controllable glycosylation reactions have been integrated …
Article
Virus-like Particles as Therapeutic Moieties of the Future
They have also found use in numerous other fields including biocatalysis, energy production, development of nanomaterials (6), antibody purification (1), antigen screening (3), and tissue engineering …