Search results for " downstream"
Article
Single-Use Technologies Prove Effective for Viral Vector Process Development
Challener
Upstream viral-vector processes can have significant impacts on downstream purification requirements. The presence of serum, culture harvest viability, turbidity, cell lysis r…
Article
Improving mAb Manufacturing Productivity by Optimizing Buffer and Media Prep Process Flow
Buffers and salts are typically the largest constituents by volume used in the downstream processing steps for manufacturing most biopharmaceutical products. A typical monoclonal antibody (mAb) proces…
Article
Monitoring and Control of Inline Dilution Processes
Buffer management has received less attention, despite the high costs and labor-, space-, time-, and material-intensive nature of this common downstream activity. Inline dilution (ILD) combined with i…
Article
Leveraging Data for Better Biopharmaceutical Process Control
Biopharmaceutical companies are starting to use PAT in more advanced development and even some manufacturing work, while methods are also moving downstream. Francisca F. Gouveia, a biopharmaceutical p…
Article
Reducing Cross-Contamination Risks in Process Chromatography
Today, single-use bioreactors are widely used for biologic drug manufacturing, and downstream disposable technologies for commercial-scale production operations are being introduced and increasingly a…
Article
Going Small to Achieve Success on the Commercial Scale
Conducting the required number of studies on the commercial scale is not practical; scale-down models are therefore employed to determine optimum conditions for downstream separation processes, includ…
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Advances in Sterilization Technologies for Overcoming Viral-Vector Manufacturing Challenges
“All these properties must be considered and evaluated when developing upstream and downstream unit operations to obtain high-quality, stable, and sterile drug substances and drug products in high yie…
Article
Accelerating time to market through process innovation
Topics include:
- Next generation upstream process enablers
- Developing continuous downstream processing
- Aseptic filling
View the agenda and register here
Article
What is process development?
Bioprocess development is often divided into upstream process development and downstream process development. Those activities must be combined with the right analytics, so you can accurately measure …
Article
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Why use mechanistic modeling in downstream process development?
With mechanistic models, process developers can get a better understanding of both the entire process and the parameters that can …