Search results for " downstream"

Article Create Digital Twins of your Chromatography Processes
GoSilico™ Chromatography Modeling Software creates digital twins of downstream processes using mechanistic models. LEARN MORE >>

Article Top Process Development Trends for 2021 and a Look into 2022
But many challenges are associated with the process development for the downstream purification of these molecules. Peter Guterstam, Ph.D., product manager of next generation resins & technologies …

Article Optimization of a Two-Step Purification Method for Bispecific Antibodies
Alligator and Cytiva developed an efficient downstream purification process for a cancer immunotherapy bispecific antibody (bsAb).  Read more

Article Maximum Output Starts with Optimized Upstream Processing
CDMOs [contract development and manufacturing organizations] must provide flexibility to address bottlenecks, like taking the most streamlined path possible, decoupling upstream and downstream process…

Article Efficient Sodium Hydroxide Sanitization with a Novel Procedure of AxiChrom™ Columns Packed with Chromatography Resin
Read full study>> Sodium hydroxide (NaOH) cleaning-in-place is the widely accepted method of sanitization employed by biopharmaceutical manufacturers to avoid the excessive costs and delays of a…

Article Common Challenges in Cross-Functional Process Development
Topic covered include: 1:28 – Common stumbling blocks in developing an effective bioprocessing operation 2:18 – Should upstream and downstream processes be developed concurrently or sepa…

Article Basics in Process Development for Biotherapeutics
Click here to learn more >> Definitions, activities, and things to consider when developing an upstream or downstream bioprocess.

Resource Protein A Fiber Chromatography from Research to Scale-up and Manufacturing of Monoclonal Antibodies
The time savings in downstream processes are also significant. Screenings of different buffer conditions and lifetime studies, including hundreds of cycles, can be performed in less than 24 hours. On …

Article High-Throughput Process Development in Biopharma
… Enables reduction of sample amount used Explore how HTPD can help accelerate the development of downstream processes. Click here to learn more >>

Article Improving Upstream Predictability
“We’re seeing shrinking process footprints through continuous integration and connection of upstream and downstream processing,” he says. The end result will be lower capital investment cost…

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