Search results for " downstream"
Article
Create Digital Twins of your Chromatography Processes
GoSilico™ Chromatography Modeling Software creates digital twins of downstream processes using mechanistic models.
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Article
Top Process Development Trends for 2021 and a Look into 2022
But many challenges are associated with the process development for the downstream purification of these molecules.
Peter Guterstam, Ph.D., product manager of next generation resins & technologies …
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Optimization of a Two-Step Purification Method for Bispecific Antibodies
Alligator and Cytiva developed an efficient downstream purification process for a cancer immunotherapy bispecific antibody (bsAb).
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Article
Maximum Output Starts with Optimized Upstream Processing
CDMOs [contract development and manufacturing organizations] must provide flexibility to address bottlenecks, like taking the most streamlined path possible, decoupling upstream and downstream process…
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Efficient Sodium Hydroxide Sanitization with a Novel Procedure of AxiChrom™ Columns Packed with Chromatography Resin
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Sodium hydroxide (NaOH) cleaning-in-place is the widely accepted method of sanitization employed by biopharmaceutical manufacturers to avoid the excessive costs and delays of a…
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Common Challenges in Cross-Functional Process Development
Topic covered include:
1:28 – Common stumbling blocks in developing an effective bioprocessing operation
2:18 – Should upstream and downstream processes be developed concurrently or sepa…
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Basics in Process Development for Biotherapeutics
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Definitions, activities, and things to consider when developing an upstream or downstream bioprocess.
Resource
Protein A Fiber Chromatography from Research to Scale-up and Manufacturing of Monoclonal Antibodies
The time savings in downstream processes are also significant. Screenings of different buffer conditions and lifetime studies, including hundreds of cycles, can be performed in less than 24 hours. On …
Article
High-Throughput Process Development in Biopharma
… Enables reduction of sample amount used
Explore how HTPD can help accelerate the development of downstream processes.
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Article
Improving Upstream Predictability
“We’re seeing shrinking process footprints through continuous integration and connection of upstream and downstream processing,” he says.
The end result will be lower capital investment cost…