Search results for " downstream"
Article
State of the Biopharmaceutical Industry: Lessons from 2018 Survey Data
Downstream is where all the problems continue to be, with purification overall lagging in productivity and speed versus upstream processing, often causing bottlenecks downstream. Bioprocessing profess…
Article
Development of Purification for Challenging Fc-Fusion Proteins
Particularly for Fc-fusion proteins, these improvements have resulted in a new set of starting conditions for downstream processing, including elevated levels of high molecular weight species (HMWs; u…
Article
Selecting the Right Viral Clearance Technology
Many methods to choose from
There are numerous methods that can be employed to achieve viral clearance during downstream biopharmaceutical processing, some that are better understood than others. …
Article
Viral Clearance Challenges in Bioprocessing
42-44
Removal and inactivation of adventitious and endogenous viruses have traditionally been achieved during the downstream purification of biologics. Viral clearance is assessed in small-scale te…
Article
High-Throughput Process Development in an Historical Environment
About 100 delegates from 13 different countries joined the discussions on HTPD case studies in upstream, downstream, and formulations, as well as modeling, data analysis, and analytics. A new session …
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Q&As with Industry Leaders
…alytical Scientist of Manufacturing Sciences, Cytiva
Tools and Methodologies for Smarter Downstream Process Development
Gayle S. Putrich, BioPharm International
John Scibetta, Adv…
Article
Sign-up to join Chromatography Virtual Summit 2022
High-level agenda:
• 15 November: Process development of antibody variants
• 16 November: In silico downstream process development — Get started
• 17 November: In silico downstream …
Article
Explore the Process Intensifier App
• Downstream capture (protein A step) operations: explore the possibilities of high-capacity resins, Fibro rapid cycling, and continuous multicolumn chromatography.
• Both as a connected operati…
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Insights and Strategies for Successful Development of Scalable AAV Processes: Part 2 of 2
…design of experiments to create a robust production process
4:00 – Three strategies for the downstream aspects of successful AAV production, which include starting out with good upstream mater…
Article
Top Challenges to Overcome When Developing AAV Processes: Part 1 of 2
…3:09 – Parameters evaluated for AAV plasmid transfection
4:27 – Three main challenges for downstream AAV process development, including cell lysis and the polishing step for full capsid enrich…