Search results for "downstream" in Articles / App Notes
Article
Webinar: Optimizing a HIC step with HTPD
Webinar date: Wed, Mar 8, 2023 11:00 AM EST (5:00 PM CET)
This webinar discusses a step-by-step workflow for optimizing a hydrophobic interaction chromatography (HIC) step.
Thi…
Article
Good Modeling Practice
How to ensure accurate model calibration for your mechanistic models.
Mechanistic models have become a very promising technique to describe chromatography processes. These models …
Article
New hydrophobic interaction chromatography (HIC) handbook
Hydrophobic interaction chromatography (HIC) separates biomolecules under mild conditions according to differences in molecular hydrophobicity. HIC is often used as a next step to purify prote…
Article
FAQ: Scale-up and scale-down with mechanistic modeling
A mechanistic model can simplify your process development projects. The model eases scale-up and scale-down between lab scale and production scale. To apply model-based scale-up and scale-down…
Article
Optimization of an antibody polishing step
Antibody purification processes are typically developed using a platform approach. Optimal operating conditions for single units are found by altering just a few process parameters with De…
Article
Quality by design in biotherapeutics purification white paper
Learn how understanding and addressing variability sources can help you develop robust chromatography processes. The principles and methodologies of biopharmaceutical manufacturing are well …
Article
Simulating chromatography processes in the growing molecular diversity
The increasing complexity and diversity of development pipelines poses new challenges for product manufacturing. Mechanistic modeling can play a key role in overcoming these challenges as they…
Article
Rethinking ion exchange chromatography modeling
In the early days of modeling, mechanistic models for ion exchange chromatography were mostly based on stoichiometric equations. A new adsorption isotherm class was introduced in 2021: the co…
Article
Accelerating VLP purification process development
See how using mechanistic modeling can speed up the purification process development of virus-like particles (VLPs).
Indeed, a method for the large-scale production of VLPs is produ…
Article
Advanced therapeutics process development using mechanistic modeling
Guterstam
Watch the interview of Peter Guterstam and Nick Whitelock (Cytiva), and learn about
the biological background of advanced therapeutics
what mechanistic modelling …