Search results for "downstream" in Articles / App Notes
Article
A deep dive into optimizing AAV capture and polishing to maximize both yield and purity
As demand for AAV vectors grows, so does the need for scalable and cost-efficient purification processes. It’s critical to maximize both overall yield and removal of impurities, including empt…
Article
Report from the 6th International HTPD Conference
Learn more about the GoSilico™ chromatography modeling software
HTPD is used beyond downstream today
As one proof point that HTPD is not only a downstream approach today, the keynote lec…
Article
Digitalization: The Route to Biopharma 4.0
Similar studies have also been conducted in downstream processing unit operation. Data-driven models have been used for predicting product recovery and optimization (8). Recently, a hybrid modeling ap…
Article
Master the basics of UNICORN™ method editing with a free online course
This free interactive course explains how to create and edit methods in
UNICORN™ software for ÄKTA™ chromatography systems.
Review the basics and learn how to use predefined phases…
Article
Mechanistic modeling quiz: Test your knowledge
Mechanistic models make it possible to create computer simulations of chromatograms. The simulations are based on physiochemical phenomena known to occur in chromatography. The benefit of in …
Article
Antibody purification quiz
How well do you know antibodies and antibody purification?
Test your knowledge and gain insights in the purification of antibody variants – bsAbs, Fab, dAbs.
Article
Accelerating CMC - The future of process development is in silico
Presented by Per Liden, General Manager, GoSilico at Cytiva.
Simulation for in silico process development is becoming a viable option to reduce the time needed for chemicals, manufacturin…
Article
Developing a HIC polishing step for removal of mAb aggregates
This article describes the development of a flow-through (FT) polishing step using hydrophobic interaction chromatography (HIC) to remove mAb aggregates.
It includes:
- The use of HTPD plate…
Article
Process Development and Control for New Modalities
Increasing molecular diversity leads to more challenges in process development and control. Advancements in technology for manufacturing and online analytical monitoring have not caught up…
Article
Chromatography Process Development Going Smarter
In this presentation, Henrik Ihre, business leader at Cytiva, outlines some industry drivers to go smarter and faster in process development as well as insights on the evolution of process…