Search results for " yield"
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Lessons Learned Accelerate Vaccine Development
Access to the infrastructure necessary for large-scale vaccine production is also essential, and a technology that provides high yields at low volumes is preferable,” he states.
That deep understa…
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A Risk-Based Genetic Characterization Strategy for Recombinant CHO Cell Lines Used for Clinical and Commercial Applications
Although the truncated LC was effectively removed through the downstream purification process, the overall purification yield was significantly reduced (to approximately 10%). A new production cell li…
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Antibody Production in Microbial Hosts
The authors review the status of expression of antibodies in microbial hosts and present the recent advances in the production of aglycosylated antibodies in bacteria.
By Anurag S. Rathore, Jyot…
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Tools for Continuous Bioprocessing Development
Ram
In semiconductor manufacturing, for example, a thorough understanding of process variation allows companies to manufacture circuits with billions of transistors at high yields. These variations…
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Applications of Surface Plasmon Resonance for Detection of Bispecific Antibody Activity
During process development, the goals are to obtain high product yield and a good process economy; to ensure that properties related to initial CQAs are maintained; and to secure that the process itse…
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The Metrics of Quality Culture
Indirect product-quality metrics could include environmental monitoring, water trend results, and yield rates. When establishing site metrics, the company could look at inspection history including in…
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Fluid Handling in Biopharma Facilities
On the other hand, readdressing fluid handling capacity and functionality within an existing facility can yield substantial operational and cost benefits. Here as well, conceptual work pertaining to p…
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Biopharma Advances Demand Specialized Expertise
Processing approaches won’t change in terms of technology, but there will be a greater emphasis on operational excellence to reduce costly inefficiencies and improve yields from bioprocesses. As more …
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Advanced Technologies Facilitate Scale-up and Technology Transfer
Another trend driving interest in modular technologies is a reduction in production volumes due to the switch to distributed production, increasing yields, and the trend towards personal medicine. “Sm…
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Continuous Chromatography: Trends, Definitions and Approaches