Search results for " yield"
Article
Vaccine Development and Production Challenges Manufacturers
Researchers are looking for formulations that reduce cold-chain requirements, methods to boost process yield, and new approaches to document product quality.
Some global health advocates, however, …
Article
The Bullish Outlook for Biosimilars
While these strategies have yielded short-term success for some organizations, they are not sustainable. Long-term success for originator manufacturers will require a different strategic approach.
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Trends in Single-use Bioreactors
In addition, there are improved control systems that allow multiple unit operation and sophisticated feed strategies improving cell yield and increasing titer with single-use bioreactors. Ergonomic fe…
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New Era for Generic Drugs
In addition to assessing non-clinical and clinical data requirements, sponsors must weigh the costs and efficiencies of in-house production versus contract manufacturing in terms of production yield, …
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Biopharma Manufacturers Respond to Ebola Crisis
Increasing the drug’s production yield involves expanded use of tobacco leaves for antibody production in a system operated by Kentucky BioProcessing (KPB), a unit of tobacco giant Reynolds American. …
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Using Quality by Design to Develop Robust Chromatographic Methods
…or software, which allows for a more thorough understanding regarding the most suitable pH that will yield a more robust separation.
Experience with this systematic approach to method development…
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Challenges and Trends in Biopharma Facility Design
…l it at all get to market?
• Market demand
• Size and frequency of doses
• Process yields
• Manufacturing challenges and innovations
• Cost and schedule pressure
• Globalizati…
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Challenges of Protein Aggregation During Purification
“In particular, resolubilization of insoluble aggregates typically requires extra process steps and can both be very costly and compromising on the overall process yield,” adds Jagschies.
Changing…
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A Q&A With Phil Lester, co-organizer of the HTPD Conference
The goal is to purify the target protein to the highest purity and yield, using the most efficient workflows and fewest resources. We have six teams competing—they began work in January and will finis…
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Quality by Design—Bridging the Gap between Concept and Implementation
These companies have seen increased production efficiencies and yields as a result, with fewer off-specification outputs and a decrease in production recalls. Some of the leading pharmaceutical compan…