Search results for " capture"
Article
Making the Move to Continuous Chromatography
For Sulzberger, continuous chromatography should be of interest for all processes that start with a capture step and where there is a desire for straight through processing. “The premise behind contin…
Article
Best Practices for Data Integrity
It enables you to find correlations that otherwise would have been impossible or not cost effective to capture with a paper-based system.
Ideally, what you are after is a system that me…
Article
Being Thorough When Transferring Technology
Procedures that govern technical documentation requirements gated to each stage of development ensure that critical information is captured and available for tech transfer. For example, required clini…
Poster
Scale-up and process economy calculations of a dAb purification process using ready-to-use products
Purification of a domain antibody (dAb) in a chromatography capture step was successfully scaled from laboratory to pilot scale using ready-to-use equipment and ready-made buffers. The scaled-up pro…
Poster
Residual DNA analysis in influenza vaccine processing
In capture mode, recoveries of 40%–60% were achieved after elution. However, recovery could be improved by concentration determination of DNA bound to the resin.
Article
Continuous Processing for the Production of Biopharmaceuticals
Researchers have recently demonstrated the first integration of high-density perfusion cell culture with a capture step through a four-column periodic counter-current chromatography (PCC) (1). The hig…
Article
Combining Microbioreactors and Advanced Statistical Techniques to Optimize a Platform Process for a New Host-Cell Line
These principal components are arranged such that the first principal component (PC1) captures the maximum possible variance from the data set (equivalent to the line of best fit though the data set).…
Article
Continued Process Verification for Biopharma Manufacturing
One of the main struggles to resolve when implementing CPV will be to determine the types and quantity of data to be captured and analyzed. CPV can err on the side of providing too little data to the …
Article
Applying GMPs to the BioPharma Supply Chain
Deep data capture and analysis
Suppliers must have robust systems and tools for collecting data in their production processes and the causes of variation. They must be open to sharing these data w…
Article
A Platform Approach for the Purification of Domain Antibodies (Dabs)
First, a capture step using Capto™ L was used to reduce E. coli host cell proteins (ECP) and endotoxin levels.
Next, a polishing step using Capto MMC ImpRes further reduced ECP and endotoxin l…