Search results for " capture"
Poster
Case Study: Improve Process Economy by Cycling of Prepacked Chromatography Columns
As projects are scaling up to manufacturing scale, it becomes attractive to cycle equipment for specific campaigns for full capture of process economy gains. This customer case study evaluates proce…
Poster
Fast Trak Services: a collaborative project to accelerate downstream biosimilar process development
Process optimization focused on improving the affinity chromatography (AF) capture step as well as the intermediate purification and polishing steps, using hydrophobic interaction chromatography (HIC…
Article
Fusion Proteins Pose Manufacturability Challenges
Finally, Chamow adds that Protein A capture chromatography can present problems for fusion proteins, not only with respect to their acid stability, but also in terms of lower binding capacities due to…
Poster
Evaluation of Protein A resin lifetime during extensive use (overloading) in continuous chromatography mode
This application note compares the performance of MabSelect SuRe pcc resin designed for continuous capture of mAbs, with the conventional high-capacity Protein A resin MabSelect SuRe LX. The study was…
Article
Downstream Processing for Cell-Based Therapies
Acoustic filtration uses standing waves to capture, separate, and concentrate particles in a fluid without having a physical barrier (membrane or filter) like traditional filtration systems. It is, th…
Article
Mechanistic Modeling of Preparative Ion-Exchange Chromatography
The system captures the extra column volume as well as the dispersion effect of the system, thus allowing the measurement of the accutate protein and salt profile that enters and leave the column.
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Poster
Guide to modern BioProcess™ chromatography resins
Many bioprocess applications include three chromatography steps: capture to isolate, concentrate, and stabilize the protein. There is an intermediate step where bulk impurities are removed followed by…
Article
Innovation vs. Capacity: How CMOs Compete
Having well-thought-out strategies that target more attractive market segments, align capabilities to serve those segments, and capture market share are more crucial than ever for achieving healthy re…
Article
Optimize Column Loading Strategy to Gain Productivity in Protein Purification
Are you looking for a way to improve productivity in your affinity chromatography step? Have you ever applied the concept of variable loading to gain productivity? By varying residence time (RT) ove…
Article
Reporting Quality Metrics to FDA
Since the publication of FDA’s draft guidance, Request for Quality Metrics, Guidance for Industry (1), in July 2015, we have been debating how to best capture and report quality metrics in our organiz…