Search results for " techniques"
Article
Leveraging Data for Better Biopharmaceutical Process Control
Currently, we are observing a trend toward connecting process condition-monitoring to accurate product quality-control during processing, by very specific techniques such as in-situ mass spectrometry …
Article
Making the Move to Continuous Chromatography
There are several different techniques available, including simulated moving bed (SMB) and periodic counter current chromatography (PCC). The aim is the same for all: to achieve a continuous (over) lo…
Article
What's in Your SOP?
What’s in Your SOP?
SOPs need to reflect a company’s specific manufacturing or other operations, says Susan Schniepp, distinguished fellow at Regulatory Compliance Associates.
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Article
Reducing Cross-Contamination Risks in Process Chromatography
Going 3D
Advanced manufacturing techniques like 3-D printing (i.e., additive manufacturing) can bring significant benefits to manufacturing processes. For example, a 3-D printed part can combi…
Article
Handbook: Design of Experiments in Protein Production and Purification
Design of experiments (DoE) is a technique for planning experiments and analyzing the information obtained. The technique allows us to use a minimum number of experiments, in which we systematically v…
Article
Development of Purification for Challenging Fc-Fusion Proteins
Materials and Methods
Purification techniques
Feed stock: Fc-fusion proteins with an isoelectric point (pI) ranging from four to seven were expressed in recombinant Chinese h…
Article
Modeling and Miniaturization: Key Topics at Successful HTPD Conference
The second downstream session,“Case Studies Downstream Part II: Other Techniques,” chaired by Ashley Hesslein from Bayer HealthCare, not only covered additional techniques such as cross flow filtratio…
Article
Reconciling Sensor Communication Gaps
Whatever techniques are ultimately adopted, their ultimate goal must be to eliminate manual sampling and lengthy analyses, or at least, to streamline these operations so they become relevant within th…
Article
Evaluating E&L Studies for Single-Use Systems
These solutions were recirculated in each skid for a few hours up to seven days at normal process temperature, then sampled and analyzed by performing the different techniques. The reference solutions…
Poster
Residual DNA analysis in influenza vaccine processing
There are many commercially available DNA preparation kits that use different techniques to bind DNA, from spin columns with a DNA-binding membrane or resin to magnetic beads. However, these kits are …