Search results for "Protein"
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Preclinical Evaluation of Product Related Impurities and Variants
For example, the cystine/DTT ratio is governed by the number of cysteine residues in the protein and thus the number of disulfide bonds necessary for the protein to assume its functional native confor…
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ADC Development Robust Despite Lackluster Performance
Oncomatryx’s approach is to develop precision drugs that target proteins located in the tumor microenvironment, which it believes is a novel route to cancer treatment because it is directed at stromal…
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From Darwin to Recombinant Fc Multimers
IgG market will continue to dominate with 46% of market, followed by albumin, 18%, John Perkins stressed the importance of other plasma proteins to have a good process economy.
Some of the …
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Being Thorough When Transferring Technology
According to Mike Ultee, principal of Ulteemit BioConsulting, companies often fail to provide complete information about their biopharmaceutical or protein. He suggests that companies should allow eno…
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Affinity Chromatography Handbook in 3 Volumes
The technique offers high selectivity, hence high resolution, and usually high capacity for the protein(s) of interest. Purification can be in the order of several thousand-fold and recoveries of acti…
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Optimizing Resin Performance with Disposable Chromatography Solutions
The chromatography medium is the means by which protein purification is performed, and it must perform as expected, otherwise the purity of the drug can be impaired. Customers have expressed that they…
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Register to the Chromatography + Filtration Virtual Summit 2024
Learn from presentations, live Q&A, and panel discussions with your peers on recent advances in antibody, antibody variants, recombinant proteins, and gene therapy downstream applications.
Agen…
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As the therapeutic pipeline diversifies, chromatography toolboxes are expanding.
For traditional mAbs, protein A chromatography is used to capture antibodies. Depending on the structure of the target antibody and the impurity profile, other affinities, like protein L or variants o…
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Choose your Optimal Wavelength for Chromatography
…your purification is readily available
For customers with a focus on emerging molecules, proteins, peptides and nucleic acid, ÄKTA pure™ chromatography system is flexible and intuitive, an…
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Chromatography for the Diversified Antibody Pipeline
We maintained a good track record of using the protein for capturing the step of bispecific antibodies. It may place more work on the main polishing steps, however, MabSelect may interact with the cla…