Search results for "purification" in Articles / App Notes
Article
Using Single-Use Technologies in Downstream Processing
Material compatibility could also be an issue for downstream steps where organic solvents or harsh chemicals are used as part of a purification process. If there is not sufficient level of review to c…
Article
Handbook: Size Exclusion Chromatography Principles and Methods
This handbook describes the use of SEC for the purification and separation of biomolecules, with a focus on practical information for obtaining the best results. The media available, selection crite…
Article
Tackling Analytical Method Development for ADCs
… conjugation sites, average DAR, and free drug content, although these methods are not suitable for purification and characterization of ADCs produced using linkage through lysine residues due to the…
Article
Fermentation for the Future
“From a process perspective, soluble expression is also beneficial for establishing automated bioprocessing with cultivation and purification closely linked and supported by timely analysis,” Reinisch…
Article
Technologies and Practices Must Evolve to Meet Demand
Purification, stability, scale up, and achieving adequate expression levels of product were the top challenges identified by manufacturers of nucleic-acid based drugs in the 2015 survey, similar to th…
Article
Improving PAT for Biologics
The complexity of biopharma processes requires innovative solutions.
Dec 01, 2014
By Cynthia Challener, PhD
BioPharm International
A key component of the quality-by-design (QbD) ap…
Article
New Era for Generic Drugs
…cturing in terms of production yield, media costs, disposable versus fixed production train, needed purification steps, and fill/finish arrangements.
The generic-drug industry is “at a crossroads,…
Article
Application of Quality by Design to Viral Safety
However, the benefits include operational flexibility, as future modifications to the purification method that remain within the process design space are not considered changes and do not require addi…
Article
Pharma Investments Reflect Key Industry Trends
Novo Nordisk: Novo Nordisk is constructing a $100 million, 29,100-square-foot purification pilot plant at its new research and development facility in Denmark to expand its capacity for early-phase di…
Article
Single-Domain Antibodies for Brain Targeting
Single-domain antibodies are emerging as credible alternatives due to their target specificity, high affinity, and cost-effective recombinant production.
Smaller recombinant antibody fragments a…