Search results for "bioreactor" in Articles / App Notes
Article
Securing the Single-Use Supply Chain
“Genentech recently presented a proof-of-concept design for a single-use bioreactor that could work with top- and bottom-mounted bags from two different suppliers. The next step is convincing manageme…
Article
High-Throughput Process Development in an Historical Environment
Several new equipment and innovations were introduced to the market, such as micro bioreactors in the 10-15 ml scale, controlled by an automated workstation. As an example of their utilization, Chris …
Article
Challenges and Trends in Biopharma Facility Design
In the case of producing a blockbuster drug, a large-scale stainless steel facility might actually be the most economical choice, especially if you have low titers and are starting from high-volume bi…
Article
Pharma Investments Reflect Key Industry Trends
The company is also investing $70 million to complete the second phase of an expansion of its East Greenbush, NY facility, which will include the addition of two 10,000-liter bioreactors.
Roche: F…
Article
Q&As with Industry Leaders
…plication, R&D, Cytiva
Current Techniques and Challenges Presented in Scaling Between Bioreactors
Jeanne Linke Northrop, BioPharm International
Andreas Castan, Strategic Techn…
Article
Q&A with Industry Leader Konstantin Konstantinov, Genzyme Vice-President
But with continuous processing, once the protein is secreted from the cells it can be taken out of the bioreactor and purified immediately, so there’s no degradation.
Up until a few years ag…
Article
Determining Criticality, Part Two: DoE and Data-Driven Criticality
Areas considered for experimental scale include, but are not limited to:
• Aspect ratios of bioreactors and mixing tanks
• Impeller number, size, and location
• Aeration method and effecti…
Article
Comparing Protein A Resins for Monoclonal Antibody Purification
The calculations are based on an annual mAb production amount of 500 kg and bioreactor size of 10,000 L for 1 g/L titer or 5000 L for 3 g/L and 5 g/L titers. Column diameter was estimated by consideri…
Article
The Development and Application of a Monoclonal Antibody Purification Platform
Early Platform Modifications
The original process was developed at Pfizer for a 500-L scale bioreactor. To accommodate an expanding pipeline, the scale of clinical manufacture was increased to 1,2…
Article
Quality by design for biotechnology products—part 1
For the reactor expansion unit operation, for example, the cell growth, viable cell density, culture viability, and glucose concentration may be affected by the inoculum, medium, bioreactor operation,…