Search results for "bioreactor" in Articles / App Notes
Article
Selecting a Comprehensive Bioburden Reduction Plan
Souza: Biologics may be at risk for contamination from fungus, bacteria, mycoplasma, and virus in the bioreactor depending on raw material source. Risk of mycoplasma contamination in raw materials may…
Article
Cleaning of Dedicated Equipment: Why Validation is Needed
If they use disposable equipment, such as single-use bioreactors, compatibility of the disposable equipment with the process should also be assessed.
Companies manufacturing only one product use d…
Article
Advanced Technologies Facilitate Scale-up and Technology Transfer
He adds that better-designed model bioreactor, chromatography, and filtration systems are allowing for even smoother scale-up and tech-transfer operations.
Raw material choices are also being adju…
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Biomanufacturing Outsourcing Globalization Continues
For example, Cytiva built two facilities in China for CMO JHL Biotech, including a KUBio modular biopharma factory in Wuhan that will house 2000-L single-use bioreactors (4). Pall Corp. opened its Lif…
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Optimization of Protein Expression in Escherichia Coli
It is important to consider the entire process—from vector and insert design to bioreactor conditions—because each part of the process will have a huge impact on the final result.
References
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Article
Use of Multivariate Data Analysis in Bioprocessing
Researchers have applied PCA to monitor a bioreactor producing Penicillin acylase in Bacillus by generating online multivariate control charts (10). The dataset contained information exclusively relat…
Article
Modular Manufacturing Platforms for Biologics
While large-scale bioreactor systems may require a traditional facility design, he says that once harvest volumes are concentrated via ultrafiltration, podular processes can resume. “Because it is com…
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Re-use of Protein A Resin: Fouling and Economics
These resins have been designed to keep pace with increasing bioreactor volumes and cell-culture expression levels and thereby prevent Protein A capture from becoming a bottleneck in the purification …
Article
Fermentation for the Future
The 15-mL bioreactor is based on single-use technology and allows up to 48 parallel fermentations. It also integrates with BI’s modular vector technology for optimized cloning and genomic expression. …
Article
What Drove Biopharma Development in 2014?
…n notes and articles, such as Highly efficient inoculum propagation in perfusion culture using WAVE Bioreactor™ systems.
This year, PDF will continue to report on industry trends that interest …