Search results for "bioreactor" in Articles / App Notes
Article
Accelerated flavivirus vaccine production with modern tools and solutions
Single-use production bioreactors and chromatography purification columnsmitigate cross-contamination risk and support increased operator safety, while reducing time to market by eliminating costly an…
Article
Cost Considerations Drive Lean Technology in Biopharmaceutical Manufacturing
EBA combines filtration, centrifugation, and chromatographic separation into a single step and can handle high-density cell feeds directly from the bioreactor.
Nanofiber adsorbants are another res…
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Automating Processes in Upstream Processing
BioPharm: What should be considered when developing strategies for process control in upstream processing?
Marshall: The bioreactor or fermenter is the upstream equipment that has the most control…
Article
Advancing Single-Use Technology Through Collaboration
…, and so the main difference between that and a system that uses fully single-use technology is the bioreactor, which is far upstream: there are significant purification processes in place further do…
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Improving Process-Scale Chromatography
The commercial-scale unit has up to eight chromatography columns in the single-use flow path and the ability to purify target biomolecules from bioreactors up to 2000 L in size within a 24-hour operat…
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Mixing dynamics in a large volume single use mixer
Large volume single-use technology mixers can be used for mixing operations throughout the entire bioprocess workflow. Large-volume mixers are mainly required in clinical three-scale and production…
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Microbiological Testing: Time is of the Essence
Assays that can be performed near the bioreactor location and in real time are definitely the assays for the future.
References
1. International Council for Harmonisation, Q5A (R1) Viral Safety …
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Managing Biomanufacturing Capacity Expectations
He adds that to meet uncertain or changing demands, one strategy is to “number up,” or use multiple single-use bioreactors to achieve a range of upstream scales. Galliher concurs that adding extra ope…
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A Q&A on Bioprocessing Trends and Technologies at INTERPHEX 2016
A number of equipment manufacturers announced new bioreactors, fermenters, tanks, and other process-related equipment as the move toward single-use systems in commercial manufacturing moves forward.
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Article
E. coli growth and Dab expression in single-use and stainless steel fermentors
This application note describes the performance of the Xcellerex™ single-use XDR-50 MO stirred-tank fermentor in an E. coli domain antibody (Dab) production process developed for a stainless steel …