Search results for "bioreactor" in Articles / App Notes
Article
Putting Viral Clearance Capabilities to the Test
On the other hand, the laboratory model viruses have a great chance of contaminating bioreactors using continuous cell lines.”
Gilljam identified other challenges. “Due to the volume tested in the…
Article
Achieving Efficient Adenovirus Upstream Production
This application note describes the production of adenovirus in HEK293 suspension cells in a bioreactor system. Triplicate cultures demonstrate a reproducible and robust batch production of adenovirus…
Article
Leveraging Data for Better Biopharmaceutical Process Control
As she says, “PAT is not just sticking a probe into a bioreactor. A great deal of work is needed to make advanced process monitoring and control approaches feasible.” At this point, due to higher comp…
Article
Modern Manufacturing Key to More Effective Vaccines
Modern Manufacturing Key to More Effective Vaccines
Accelerated development of new preventives raises challenges for efficient CMC evaluation and production.
By Jill Wechsler
…
Article
FDA Framework Spurs Advanced Therapies
Need for new manufacturing technology
Indeed, developers of new regenerative medicines will require robust platform processes, such as automation technologies and 3-D bioreactors, to maintain cons…
Article
Performance of Single-Use Xcellerex™ XDR‑500 MO and XDR‑50 MO Stirred-Tank Fermentor Systems
This application note describes the performance of the XDR‑500 MO fermentor system in comparison with the XDR‑50 MO fermentor. Domain antibody production in E. coli was used as the model process. …
Article
Modeling and Miniaturization: Key Topics at Successful HTPD Conference
The “Case Studies Upstream” session was chaired by Jonathan Coffman from Boehringer Ingelheim, and reviewed several cases in which recent advances in high-throughput automated minibioreactor systems i…
Article
Evaluation of HEK293 Cell Growth and Adenovirus Productivity in HyClone™ CDM4HEK293 Medium
This application note demonstrates growth of HEK293 cells in CDM4HEK293 medium in both shake flask and bioreactor cultures. Adenovirus productivity was evaluated in shake flask cultures. Performance i…
Article
Mechanistic Modeling of Preparative Ion-Exchange Chromatography
Figure 2: A typical setup of a bioreactor system model along with a chromatography column. The delay volumes are modeled as a chain of continuous stirred tank (CSTR) and dispersed plug flow (DPFR) rea…
Article
Speed and Flexibility Are Dual Goals for Biopharma Operations
What new technologies and products are impacting bioprocessing operations?
Recent product introductions for bioprocessing operations—such as advances in bioreactor technology, media, buffers, and …