Search results for "bioreactor" in Articles / App Notes
Article
Scale-Up Model of a mAb Process from Microbioreactor to XDR-1000
All investigated bioreactor systems displayed similar trends over time and acceptable variability between cultures for viable cell density and viability profile, product titer, lactate, and product qu…
Article
Single-Use for Downstream Chromatography: Benefit or Hindrance?
…the unit operation cost was 19% to 33% less for a membrane process used on 1000-L and 5000-L scales bioreactor volumes and various mAb titres. In addition, buffer volume was decreased by up to 55%. F…
Article
The Outlook for CMO Outsourcing in 2019
The industry is starting to see a major trend for CMOs adding 1000–2000-L single-use bioreactor process lines for commercial manufacturing as products currently in development manufactured with single…
Article
Perfusion Culture Using TFF or ATF as Cell Retention Method
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Perfusion processes have many advantages such as being favorable for product quality and supporting efficient facility utilization by offering the possibility…
Article
Scalable Viral Vector Manufacturing
For example, single-use bioreactors, filtration, and chromatography techniques are suitable for virus production.
Due to the diversity of viruses, platform solutions are challenging to implement e…
Article
Optimization of Fed‑Batch Culture Conditions for a mAb‑Producing CHO Cell Line
The selected fed-batch culture conditions supported mAb titers of approximately 4 g/L in bioreactor cultures.
Article
State of the Biopharmaceutical Industry: Lessons from 2018 Survey Data
The continued relative lack of single-use microbial bioreactors and suppliers/vendors continuing to promote standardized (versus new) approaches (i.e., use of CHO and similar host cell lines) are fact…
Article
The Challenge of Disruptive Technologies in Bioprocessing
“One issue that could occur is the load of a high titer product stream from a large-volume bioreactor onto a column with given, limited size and thus limited capacity (similar with filters), and all o…
Article
Biopharma Seeks Balance
…nucleation for lyophilization processes, predictive modeling for process monitoring and closed loop bioreactor control, next-generation sequencing, continuous manufacturing for downstream processes, …
Article
Fifteen Years of Progress: Biopharmaceutical Industry Survey Results
WuXi Biologics, “WuXi Biologics to Invest €325 Million to Build Largest Biomanufacturing Facility Using Single-Use Bioreactors in Ireland,” Press Release [4], April 30, 2018.
5. R.A. Rader, E.S.…