Search results for " Downstream PD"
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Process Development and Control for New Modalities
Increasing molecular diversity leads to more challenges in process development and control. Advancements in technology for manufacturing and online analytical monitoring have not caught up…
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Chromatography Process Development Going Smarter
In this presentation, Henrik Ihre, business leader at Cytiva, outlines some industry drivers to go smarter and faster in process development as well as insights on the evolution of process…
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Webinar: Optimizing a HIC step with HTPD
Webinar date: Wed, Mar 8, 2023 11:00 AM EST (5:00 PM CET)
This webinar discusses a step-by-step workflow for optimizing a hydrophobic interaction chromatography (HIC) step.
Thi…
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Good Modeling Practice
How to ensure accurate model calibration for your mechanistic models.
Mechanistic models have become a very promising technique to describe chromatography processes. These models …
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New hydrophobic interaction chromatography (HIC) handbook
Hydrophobic interaction chromatography (HIC) separates biomolecules under mild conditions according to differences in molecular hydrophobicity. HIC is often used as a next step to purify prote…
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FAQ: Scale-up and scale-down with mechanistic modeling
A mechanistic model can simplify your process development projects. The model eases scale-up and scale-down between lab scale and production scale. To apply model-based scale-up and scale-down…
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Optimization of an antibody polishing step
Antibody purification processes are typically developed using a platform approach. Optimal operating conditions for single units are found by altering just a few process parameters with De…
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Quality by design in biotherapeutics purification white paper
Learn how understanding and addressing variability sources can help you develop robust chromatography processes. The principles and methodologies of biopharmaceutical manufacturing are well …
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Simulating chromatography processes in the growing molecular diversity
The increasing complexity and diversity of development pipelines poses new challenges for product manufacturing. Mechanistic modeling can play a key role in overcoming these challenges as they…
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Rethinking ion exchange chromatography modeling
In the early days of modeling, mechanistic models for ion exchange chromatography were mostly based on stoichiometric equations. A new adsorption isotherm class was introduced in 2021: the co…