Search results for " Downstream PD"
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Exploring the world of antibodies: mAbs, Fabs, dAbs, and bsAbs
There is a vast array of antibody variants, including multispecific (msAb), bispecific antibodies (bsAb), antibody fragments (Fab, dAb, scFv), and antibody-drug conjugates (ADC). But with this…
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Video: Standardize recombinant protein purification process development
Cytiva™ Protein Select™ resin is an affinity chromatography resin for purifying recombinant proteins using the self-cleaving Cytiva Protein Select tag. During an affinity step performed with C…
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A deep dive into optimizing AAV capture and polishing to maximize both yield and purity
As demand for AAV vectors grows, so does the need for scalable and cost-efficient purification processes. It’s critical to maximize both overall yield and removal of impurities, including empt…
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Report from the 6th International HTPD Conference
The biggest challenge is still the people and Quantitative Structure-Activity Relationship (QSAR) plus mechanistic modeling were two key take-home messages from the 6th International conference devote…
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Digitalization: The Route to Biopharma 4.0
Industry 4.0, also known as the Fourth Industrial Revolution (4IR), will result in the digital transformation of the manufacturing sector. It is propelled by transformative trends such as the prolif…
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Master the basics of UNICORN™ method editing with a free online course
This free interactive course explains how to create and edit methods in
UNICORN™ software for ÄKTA™ chromatography systems.
Review the basics and learn how to use predefined phases…
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Mechanistic modeling quiz: Test your knowledge
Mechanistic models make it possible to create computer simulations of chromatograms. The simulations are based on physiochemical phenomena known to occur in chromatography. The benefit of in …
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Antibody purification quiz
How well do you know antibodies and antibody purification?
Test your knowledge and gain insights in the purification of antibody variants – bsAbs, Fab, dAbs.
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Accelerating CMC - The future of process development is in silico
Presented by Per Liden, General Manager, GoSilico at Cytiva.
Simulation for in silico process development is becoming a viable option to reduce the time needed for chemicals, manufacturin…
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Developing a HIC polishing step for removal of mAb aggregates
This article describes the development of a flow-through (FT) polishing step using hydrophobic interaction chromatography (HIC) to remove mAb aggregates.
It includes:
- The use of HTPD plate…