Search results for " optimization" in Articles / App Notes

Article Top Process Development Trends for 2021 and a Look into 2022
However, the focus in 2021 shifted beyond the pandemic to optimization and scaling up adeno-associated virus (AAV) production, process workflows and considerations for messenger RNA (mRNA) therapeutic…

Article Gene Therapies Push Viral Vector Production
“On the technical side we must improve titer upstream (high titer stable producer cell line and/or cell line and media optimization) and for AAV specifically, improve ratio of full versus empty capsid…

Article Biopharmaceutical Process Development: 2018 Lessons and 2019 Predictions
…fers are made to specification?”    Also popular in 2018 was an article covering the optimization of fed‑batch culture conditions, which describes a broadly applicable and efficient workflow fo…

Article Ensuring Viral Safety of Viral Vaccines and Vectors
Ensuring Viral Safety of Viral Vaccines and Vectors Viral vaccines and viral vectors used in biotherapeutic applications carry the risk of microbial contamination, which must be addressed. …

Article Downstream Processing for Cell-Based Therapies
For example, several studies have investigated the optimization of cell-expansion processes of adherent human cells. Significant progress has been made in recent years with human mesenchymal stem cell…

Article Impact of Manufacturing-Scale Freeze-Thaw Conditions on a mAb Solution
The objective of this study was to assess the impact of manufacturing-scale, freeze-thaw conditions on aggregation and subvisible particle formation of a monoclonal antibody solution (mAb-A; IgG1) u…

Article Mechanistic Modeling: Does it Have a Future in Process Development?
The application of mechanistic models for process development and optimization has been a topic of discussion in the pharmaceutical industry for many years. Mechanistic models are considered as an a…

Article Improving PAT for Biologics
…liable single-use sensors that enable the application of PAT as a basis for effective automation and optimization, according to Becker. “In addition to established multi-use offline sensor technologi…

Article High-Throughput Process Development in an Historical Environment
Traditionally, optimization of the refolding steps has been considered a bottleneck during downstream process development. In the presented work, instead an automated platform using 96-well plates for…

Article Using Quality by Design to Develop Robust Chromatographic Methods
In the example, the data from the six experiments are used as the input for in silico optimization experiments. The result is a resolution map and optimized chromatogram within which the optimum condi…

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