Search results for " optimization" in Articles / App Notes
Article
HT Multi-Product Liquid Chromatography for Characterization of Monoclonal Antibodies
If used correctly, these new analytical methods can reduce analysis and product development time.
ABSTRACT
Monoclonal antibodies represent a significant portion of sales in the biopharma…
Article
QbD and PAT in Upstream and Downstream Processing
In addition, as the downstream process is characterized, optimizations/changes in the downstream process can lead to the need to repeat upstream characterization efforts. Hence, the sooner a correlati…
Article
Quality by Design: A CMO's Perspective on Gaining Knowledge Faster and Better
In this example, the traditional approach involved minimizing development studies to keep costs down, waiting for clinical data to perform any further optimization, and then performing a long series o…
Article
Addressing the Challenges in Downstream Processing Today and Tomorrow
Based on the resin screening, CHA chromatography was selected for optimization. An initial test of CHA was performed using a phosphate gradient. This method allowed identification of step elution cond…
Article
Evaluating the Use of Continuous Chromatography
It has been previously noted that process optimization and controlling the steps in downstream chromatography contributes to increased consistency of product quality as well as better management of pr…
Article
Discovering the unknown: How does in silico process development change PD scientists’ work?
There, we used modeling for process optimization. This resulted in improvements in purity and yield of a mixed mode chromatography purification step, and doubled productivity. Mechanistic modeling can…
Article
Report from the 6th International HTPD Conference
McMinn presented how integration of algorithmic optimization tools with a robotic liquid handling system could enable high-throughput platform and provide improved knowledge of the IVT process.
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Article
A Look into Biologic Scale-Up Strategies
Yet, despite decades of process optimization, there remain stubborn challenges—or new challenges that have arisen–during the scale up of cell culture processes.
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Article
Developing a HIC polishing step for removal of mAb aggregates
This article describes the development of a flow-through (FT) polishing step using hydrophobic interaction chromatography (HIC) to remove mAb aggregates.
It includes:
- The use of HTPD plate…
Article
Accelerating VLP purification process development
Further, they allow for efficient process optimization in silico.
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