Search results for " cell" in Articles / App Notes
Article
Reviewing the Importance of Biosimilarity and Interchangeability
Analytical studies for determining biological activity may involve in-vitro assays, cell-based assays, or other relevant biological assays depending on the mechanism of action of the drug, Stamm remar…
Article
In silico optimization of AAV full/empty particle separation with AIEX
The separation of adeno-associated virus (AAV) with high yield and purity is an increasingly important challenge. Mechanistic modeling is the tool of choice to find the optimal AIEX chromatogr…
Article
Exosome isolation by tangential flow filtration and size exclusion chromatography
We describe an evaluation of purification workflows from three different cell culture supernatants. The workflows we describe are suitable for scale-up and combine tangential flow filtration (TFF) for…
Article
Get Started: Purification of mAb Variants - eLearning
These molecules show wider variation in binding affinities and are often more challenging to separate from impurities, such as host cell proteins (HCP), host DNA, aggregates, and isoforms.
In this …
Article
Dear lentivirus: We have not forgotten about you and how to improve your polishing recovery
Lentiviruses are commonly used for both chimeric antigen receptor (CAR) T cell therapy and ex vivo gene therapy.
Vector purification is very challenging due to low stability of these envel…
Article
Balancing AAVs Versus LLVs
The prevailing understanding is that serotypes bind to different, or have differential affinities to an array of primary cell surface glycoprotein receptors and secondary receptors.
Pharmace…
Article
HTPD 2023 conference is coming up. What will be discussed and what happened last time?
Both the evolution of mature HTPD platforms for mAbs as well as the development of new HTPD approaches for nanoparticles like cells, viral vectors et al, will be discussed.
Learn more about HTPD …
Article
Xcellerex™ X-platform bioreactor live virtual demo
Whether in pilot or cGMP facilities, the modular and application-based approach improves cell culture productivity.
In this virtual event, Ken Clapp will explain how we developed the Xcellerex™ X-p…
Article
How to program, run and evaluate a design of experiments (DoE)
An application example showcases how to optimize an antibody purification for low dimer-and-aggregate and host cell proteins (HCPs) content while achieving best possible yields.
Take the course now…
Article
Balancing innovation, speed, and robustness to improve efficiency in upstream process development.
Date: April 26, 2023 2:00pm CEST(8:00am EDT)
Register today