Search results for " cell" in Articles / App Notes
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Modern plasmid purification process
AcuraBio selects Cytiva's latest two-step purification protocol to offer a productive plasmid DNA service to its customers globally to alleviate supply constraints for mRNA and cell & gene th…
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Designing a 1.5 L Bench-Scale Model of a Perfusion Process
Establishing an appropriate model allows for higher throughput during simultaneous operation and monitoring of several cultures at different process conditions. In this article, we discus…
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Capture of Bispecific Antibodies and Removal of Product-Related Impurities
Many of these variants, especially asymmetric bispecific antibodies, are prone to aggregation or to forming product-related impurities such as homodimers and half antibodies during cell culture. The s…
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Scaling a mAb production process to Xcellerex bioreactors
Moving a monoclonal antibody production process from a microscale bioreactor to the Xcellerex XDR single-use platform.
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Intensifying your fed-batch process using cryobags
We will show that high-density cryobags can be used to seed a bioreactor at a 500-fold higher seed density, reducing the total process time by up to 9 days.
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Recombinant Adeno-Associated Virus Type 5 Production Process
A scalable recombinant adeno-associated virus (rAAV) type 5 production process was developed using transfected HEK293 suspension cells.
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Trends in Outsourcing of Bioprocess Development
Growing numbers of conventional recombinant proteins and monoclonal antibodies, as well as next-generation molecules such as multispecifics, antibody-drug conjugates, and cell and gene therapies, are …
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Register now: Viral Vector Production for Gene Therapy
In partnership with NIBRT, our eLearning course, “Viral Vector Production for Gene Therapy”, is available on the award winning NIBRT Online Academy.
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Navigating Molecular Diversity
Are you working with biomolecules beyond mAbs?
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Top Challenges to Overcome When Developing AAV Processes: Part 1 of 2
…transfection
4:27 – Three main challenges for downstream AAV process development, including cell lysis and the polishing step for full capsid enrichment
7:28 – Challenges associated wit…