Search results for " cell" in Articles / App Notes

Article Single-Domain Antibodies for Brain Targeting
Inappropriate activation of the Fc receptor-expressing cells by antibodies can lead to cytokine release and toxicity. On the other hand, their long circulation half-life results in poor contrast in im…

Article ADC Development Robust Despite Lackluster Performance
The agent is internalized by the tumor cell after it is bound to the cell by the mAb end of the ADC molecule. Inside the tumor cell, the ADC breaks down into its components, which releases the cytotox…

Article Witnessing Major Growth in Next-Generation Antibodies
Drug developers are, however, improving linker technologies and the specificity of newer ADC products, such as the targeting of dividing cells vs. non-dividing cells, and Scott Koenig, president, CEO,…

Article Trends in Single-use Bioreactors
In addition, there are improved control systems that allow multiple unit operation and sophisticated feed strategies improving cell yield and increasing titer with single-use bioreactors. Ergonomic fe…

Article Maximum Output Starts with Optimized Upstream Processing
…clonal antibodies (mAbs) to advanced multispecifics, antibody-drug conjugates, viral oncolytics, and cell, gene, and gene-editing therapies—was occurring worldwide before the emergence of the COVID-1…

Article Preclinical Evaluation of Product Related Impurities and Variants
This may be attributed to the complexities related to the use of cell lines, media formulation, and other bioprocessing steps that are prone to variability to varying degrees (4). The inherent …

Article Novel Vaccine Technologies Meet the Need for Pandemic and Therapeutic Solutions
Examples include cell-culture, synthetic DNA, chimeric antigen, and recombinant protein nanoparticle vaccine technologies. Egg-vaccine technology limitations Traditional vaccine manufactu…

Article Quality by design for biotechnology products—part 1
In some cases, an IgG1 isotype is ideal for cell killing, whereas IgG2 is a favored isotype for eliminating the effector function of an antibody on target binding. For further enhancement of cell kill…

Article Safety Drives Innovation in Animal-Component-Free Cell-Culture Media Technology
By Tom Fletcher, Holden Harris Regulatory expectations for cell-culture-based biologics production processes changed dramatically once it was discovered in 1996 that a fatal disease (variant Creut…

Article Applications of Surface Plasmon Resonance for Detection of Bispecific Antibody Activity
Blincyto targets cell surface proteins CD19 and CD3 simultaneously, helping to put T cells within reach of the targeted cancer cell with the goal of allowing the T cells to inject toxins into cancer c…

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