Search results for "single-use"
Article
New Therapies Present Scaling Challenges
It is estimated that scale-up manufacturing solutions for cell therapies will need to generate batches of up to 2000 L (3) of product using single-use, disposable technology. Dependence on single-use …
Article
Monitoring and Control of Inline Dilution Processes
“The advent of buffer concentrates delivered in single-use (SU) bags combined with automated, compact precision dilution and blending technology allows these tank farms to be repurposed for more produ…
Article
Process Economic Simulation for Scalable Production of Adenovirus
The novel process was compared with a reference process in both stainless-steel and single-use configurations across various production scales and scenarios. The process, based on modern tools and tec…
Article
Challenges in Cell Harvesting Prompt Enhancements
Challenges in Cell Harvesting Prompt Enhancements
Higher cell titers and cell densities have posed a challenge to cell harvesting, a crucial step in biologics manufacturing.
By Feliza Mi…
Article
Automation Trend in Fill/Finish Reduces Contamination Risk
… that use tool-less changeovers, in-process weight checks, self-adjusting fill volume controls, and single-use equipment/technology (4).
Fill/finish operations for biologics is largely automated a…
Article
Process Chromatography: Continuous Optimization
Single-use chromatography is another challenging area. “To date it has been difficult to provide cost-effective devices that can also be scaled up,” notes Bulpin.
Purification processes for mAbs h…
Article
Hybrid Bioprocessing: A Q&A with Andrew Sinclair
In my view, it's where within the manufacturing process, there are a combination of single-use (SU) materials and re-usable materials in contact with the process and associated fluids. This often refe…
Poster
Fast Trak Services: a collaborative project to accelerate downstream biosimilar process development
… regulatory and technical requirements in all countries where it operates, using cutting edge single-use technology. Currently, mAbxience has sales contracts in more than 70 countries.
One …
Poster
Resin selection to optimize the flexural strength of bioprocess film
However, due to the flexible nature of the plastic materials used to construct the single-use containers, the flexural properties of the bioprocess film are critical for performance in such applicatio…
Article
Accelerated flavivirus vaccine production with modern tools and solutions
Single-use production bioreactors and chromatography purification columnsmitigate cross-contamination risk and support increased operator safety, while reducing time to market by eliminating costly an…