Search results for "single-use"
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Maximum Output Starts with Optimized Upstream Processing
She points to the mAb sector where stainless-steel bioreactors with tens of thousands of liters of capacity were commonly used for cell culture, but today have been replaced with single-use (SU) biore…
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Scaling Up an E. coli Upstream Process for Plasmid DNA Production — from 2.5 to 160 L scale Fermenters
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This article summarizes the results of Escherichia coli growth performance for plasmid production in a 5 L glass fermentor, which was scaled up to 80 and 160 L scale in Xcellerex™ X…
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Cytiva Acquires Vanrx, Innovator in Aseptic Filling
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Cytiva acquires Vanrx to extend its single-use manufacturing platform with aseptic-filling solutions.
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Updating Viral Clearance for New Biologic Modalities
As an example, he points to recent studies conducted on MilliporeSigma’s single-use chromatography membrane, Natrix Q. Results showed that this chromatography membrane can work across a broad range of…
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Process Development: 2020 Reflections and 2021 Possibilities
This results in higher throughput in research and process development, allowing for new opportunities for cost efficient, single-use chromatography in large-scale commercial manufacturing.
Another…
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Akron Bio Will Install a Cytiva FlexFactory to Manufacture Plasmid DNA
Cytiva will provide its FlexFactory, a flexible, single-use platform, to enable Akron Biotech to manufacture plasmid DNA (pDNA), which is used in many innovative therapies and vaccines, Cytiva said in…
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Simplifying Cell Culture Expansion
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Controlled perfusion in a closed, single-use bioreactor can cut the complexity from your cell culture expansion process, making it possible to go from seed trai…
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Scaling a mAb Production Process to Xcellerex Bioreactors
This article discusses moving a monoclonal antibody (mAb) production process from a microscale bioreactor to the Xcellerex XDR single-use platform.
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Next Generation Process Chromatography
The platform is also compatible with existing installed infrastructure and can fully benefit from single-use operations where this is desired.
Bioprocess Development Forum: Can you shortly describ…
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Eliminating Residual Impurities Starts with a Strategic Plan
They can be derived from the host cell or the product itself, media components, surfactants, virus inactivation agents, inorganic or organic contaminants from permanent and single-use process equipmen…