This application note discloses the process economic modelling of a modern start-to-finish adenovirus production process. The novel process was compared with a reference process in both stainless-steel and single-use configurations across various production scales and scenarios. The process, based on modern tools and technologies, was generally shown to be the most cost-efficient option of the investigated alternatives. Process configurations using single-use equipment wherever possible were also shown to be more cost-effective than corresponding configurations using primarily stainless-steel equipment.
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