Search results for " DNA"
Article
Choose your Optimal Wavelength for Chromatography
U9-T monitor allows differentiation between peaks containing protein and those containing DNA/RNA, nucleic acids or nucleotides. Most proteins absorb strongly at 280 nm due to the presence of tryptoph…
Article
Maximum Output Starts with Optimized Upstream Processing
…ssen) or messenger RNA (mRNA) (Pfizer-BioNTech, Moderna), with candidates still in development being DNA-based (Scancell), protein-based (Novavax), and using more classical technology (Valneva). This…
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Cell-free Expression Systems Pose Cell Culture Alternative
…ropagate cells in batch-mode bioreactors; and a timeframe of at least 18 months to go from finalized DNA-customized cells to commercial-scale volumes of product, according to the professors.
C…
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Patenting Prospects for Cell-Based Therapies
Myriad Genetics (“Myriad”) (8), in which the Court deemed patent ineligible DNA isolated from nature (while at the same time deciding that cDNA, made from mRNA converted by the viral enzyme reverse tr…
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Platform Approach Speeds Process Development
The platform allows for the production of biopharmaceuticals for toxicological studies within approximately 14 months after receipt of DNA sequences. After an additional six months, material from GMP …
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Overview of a scale-up of a cell-based influenza virus production process using ReadyToProcess equipment
Purity was determined by measuring host cell DNA (quantitative PCR), host cell proteins (Biacore method), and total protein (Bradford method).
The results in terms of TCID50, HA yield, host…
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Quality by design for biotechnology products—part 1
Examples of process-related impurities include host cell DNA, host cell protein, adventitious agents, residual medium supplements such as protein hydrolysates, and components such as nucleases or resi…
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Modern plasmid purification process
This latest purification technology will offer efficient processing time for plasmid DNA production.
Learn more here.
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COVID-19 Diagnostics Supplier Ramps Up Production with Help of Cytiva’s Testa Center in Sweden
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In this blog post, you can learn about how Solis BioDyne, Estonian manufacturer of polymerase chain reaction/quantitative polymerase chain reaction reagents to analyze DNA f…
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Eliminating Residual Impurities Starts with a Strategic Plan
Others are more complex to define, such as those that originate from the cellular system including residual DNA or host-cell proteins (HCPs),” Wake observes. “In the latter case, for instance, conside…