Search results for " purification"
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Top Process Development Trends for 2022 and a Look into 2023
The article, “Next-generation Protein L Chromatography,” for example, begins by establishing that the diversity of antibody variants in today’s pipeline presents unique challenges for purification pro…
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Cell-free Expression Systems Pose Cell Culture Alternative
By producing less waste upstream, there is the potential benefit of having less burden downstream in the separation and purification steps. However, the practicality of using cell-free expression syst…
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Virus-like Particles as Therapeutic Moieties of the Future
They have also found use in numerous other fields including biocatalysis, energy production, development of nanomaterials (6), antibody purification (1), antigen screening (3), and tissue engineering …
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State of the Biopharmaceutical Industry: Lessons from 2018 Survey Data
Downstream is where all the problems continue to be, with purification overall lagging in productivity and speed versus upstream processing, often causing bottlenecks downstream. Bioprocessing profess…
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Ensuring Viral Safety of Viral Vaccines and Vectors
…• Eliminating contaminants by incorporating virus inactivation/removal steps into the vaccine purification process (challenging for whole live virus vaccines but practical for inactivated, subunit, a…
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The New World of Biopharmaceutical Manufacturing
… senior marketing director, Downstream Processing, Pall Life Sciences; Fritjof Linz, vice-president, Purification Technologies, Sartorius Stedim Biotech; and Eva Heintz, global market manager, Health…
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Walk Away and Do More Screening Preps
Learn how an ÄKTA pure protein purification system can be modified to increase throughput of mAb purifications and decrease hands-on time.
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Affinity chromatography Handbook: Vol. 2 Tagged Proteins
The use of recombinant proteins has increased greatly in recent years, as has the wealth of techniques and products used for their expression and purification. The advantages of using a protein/peptid…
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A Risk-Based Genetic Characterization Strategy for Recombinant CHO Cell Lines Used for Clinical and Commercial Applications
If not removed by the purification process, these unintended byproducts are typically considered product-related impurities (PRI), as defined by International Council for Harmonisation of Technical Re…
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Antibody Production in Microbial Hosts
These products have been used in biosensors, protein purification, and bioimaging (3).
Since the advent of an era of antibody-based therapeutics, the major focus of the industry has been on the ge…