Search results for " purification"
Article
Scalable Viral Vector Manufacturing
Is virus purification also challenging? Are platform solutions a realistic approach?
Yes, the purification process can be quite complex. Viruses are much larger than recombinant proteins and ant…
Article
Making the Move to Continuous Chromatography
“Multicolumn chromatography has long been an accepted continuous purification practice by small-molecule manufacturers, but is just now gaining traction in the biomanufacturing space,” he says.
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Article
Unifying Continuous Biomanufacturing Operations
Downstream continuous purification has seen some success as well, mostly through the integration of various chromatography column sequences. But the continuous production of biologics in a closed, tot…
Poster
Fast Trak Services: a collaborative project to accelerate downstream biosimilar process development
Consequently, low product recovery and purity were obtained in the first-generation purification process. In addition, the purification protocols were poorly suited for manufacturing scale.
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Article
Reconciling Sensor Communication Gaps
The desirability of platform purification, best exemplified in monoclonal antibody (mAb) downstream processing, simultaneously creates and reduces the need for extensive downstream monitoring. Platfor…
Article
Designing a Biomanufacturing Facility Incorporating Single-Use Technologies
The final yield here is determined by the product titer of the production bioreactor, combined with the efficiency of the downstream purification steps, both of which will be driven by the details of …
Article
Continuous Manufacturing: A Changing Processing Paradigm
Employing straight-through processing in mAb purification could significantly improve throughput with a much smaller manufacturing footprint, presenters of the aforementioned webinar conclude. Case st…
Article
QbD and PAT in Upstream and Downstream Processing
While scale-down models combined with screening and design space DOEs can be used to understand cell expansion and the cell-production bioreactor processes, full purification can be time consuming and…
Article
Automated Concentration and Diafiltration of Multiple siRNA Samples
The synthesis and purification unit operations of the process utilize equipment with programmed methods allowing scientists to complete their respective tasks. Manual crossflow filtration (CFF) steps …
Article
Fundamentals of hydrophobic interaction chromatography
This technique separates proteins according to differences in their surface hydrophobicity, and is suitable for the purification of a large range of molecules:
* recombinant proteins and peptides…